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Video/AnimationReConstruct – 3D Bioprinted Vascularized Fat Tissues for Breast ReconstructionBreast cancer affects 15% of all women. Current options for breast reconstruction are insufficient and have poor patient outcomes. A research team at the Wyss Institute is addressing this clinical need by fabricating vascularized adipose tissue flaps for therapeutic use. Credit: Wyss Institute at Harvard University -
Video/AnimationJanus Tough Adhesives for Tendon RepairThere is a large unmet need for tendon regeneration therapies after injury. Building upon the tough gel adhesive technologies developed at the Wyss Institute at Harvard University and the Harvard School of Engineering and Applied Sciences, researchers from these institutions collaborated with a group at Novartis to create the Janus Tough Adhesives (JTAs). This two-sided... -
Audio/PodcastOf Mice and Massage with Dr. Bo Ri SeoYou know those people who say you can’t change tissue? Well Wyss Postdoctoral Fellow Bo Ri Seo explains otherwise on this episode of BodyTalk. She is the lead writer on an exciting paper. Dr. Bo Ri Seo is a biomedical engineer who has been studying mechanobiology and mechanotherapy to develop therapeutic strategies for cancer and... -
Video/AnimationPhonoGraft: Programming the eardrum to repair itselfEardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and... -
Video/AnimationAlginate Hydrogel for AngiogenesisThis video describes how an alginate hydrogel can be used to trigger the formation of new blood vessels at an ischemic site in the body. Credit: Wyss Institute at Harvard University. -
Video/AnimationHumans of the Wyss – Faculty Edition with Mike LevinOur interview series, “Humans of the Wyss – Faculty Edition,” features Wyss Institute faculty members discussing how they think about their work, the influences that helped shape them as scientists, and their collaborations at the Wyss Institute and beyond. In the second edition of the series, Benjamin Boettner, Wyss Institute Communications team member, talks to... -
Video/AnimationSelf-regenerating bacterial hydrogels as intestinal wound patchesThis animation explains how self-regenerating bacterial hydrogels could be used as adhesive patches to help intestinal wounds heal. Credit: Wyss Institute at Harvard University. -
Video/AnimationMulti-joint Personalized Soft Exosuit Breaks New GroundA multidisciplinary team at Harvard’s Wyss Institute and Harvard SEAS has developed a mobile multi-joint soft exosuit using an automatic tuning strategy that could reduce fatigue in soldiers, firefighters or other rescue workers. Credit: Wyss Institute at Harvard University -
Video/AnimationAcoustophoretic PrintingHavard researchers have developed acoustophoretic printing, a method that uses 3D printing technology and highly localized sound waves to generate of droplets with defined sizes and a wide range of viscosities. -
Video/AnimationNew Wyss Institute Initiative – 3D Organ EngineeringWyss Institute Core Faculty members Christopher Chen and Jennifer Lewis describe the Wyss Institute’s new initiative focused on organ engineering, which leverages our expertise in biomaterials, tissue engineering, three dimensional biofabrication, and stem cell development. -
Video/AnimationTherapeutic Organ Engineering: Highlights From The 8th Annual Wyss SymposiumThe 8th Annual Wyss International Symposium focused on innovations in therapeutic organ engineering, featuring diverse speakers doing exciting work in 3D organ engineering, materials fabrication, and vascular integration. This video highlights some of the themes discussed in their presentations as well as the advances that are leading to the ultimate goals of developing new approaches... -
Audio/PodcastDisruptive: Cancer Vaccine and Immuno-MaterialsImmunotherapy – treatment that uses the body’s own immune system to help fight disease – has groundbreaking and life-saving implications. In an effort to make immunotherapy more effective, Wyss Institute researchers are developing new immuno-materials, which help modulate immune cells to treat or diagnose disease. In this episode of Disruptive, Dave Mooney, Wyss Core Faculty... -
Video/Animation8th Annual Wyss Institute Symposium: Therapeutic Organ EngineeringScreened just before the symposium opening, this animation artistically connects concepts of therapeutic organ engineering presented during the event. Credit: Wyss Institute at Harvard University -
Video/AnimationSoft Exosuit for Post-stroke Gait Re-trainingThis video explains how exosuit technology, developed at the Wyss Institute for Biologically Inspired Engineering, applied to ankle movements helps patients post-stroke regain a more normal gait. Credit: Wyss Institute at Harvard University -
Video/AnimationWyss Focus: Immuno-MaterialsWyss Core Faculty, Dave Mooney, explains our new Immuno-Materials Focus Area, which adds a new dimension to immunotherapy in that it harnesses materials to make treatments more efficient and effective. These material-based systems are capable of modulating immune cells and releasing them into the body where they can treat diseases. -
Video/AnimationPodocyte Cells: Kidney-on-a-ChipThis video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute... -
Video/AnimationSoft Robotic Heart Sleeve: In VitroReplicating heart pressure and contraction in vitro, the soft robotic heart sleeve with actuators arranged around a fluid-filled sac is able to rhythmically contract to each time pump a defined fluid volume into the attached tubing. Credit: Harvard SEAS -
Audio/PodcastDisruptive: Mechanotherapeutics – From Drugs to WearablesMechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Video/AnimationEfficient Recovery of Stem Cell SheetsSee in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University -
Video/AnimationPrinting Vascular TissuePrinting vessel vasculature is essential for sustaining functional living tissues. Until now, bioengineers have had difficulty building thick tissues, lacking a method to embed vascular networks. A 3D bioprinting method invented at the Wyss Institute and Harvard SEAS embeds a grid of vasculature into thick tissue laden with human stem cells and connective matrix. Printed... -
Video/AnimationDistributed Cell Division CounterGenetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University -
Video/AnimationCircadian TransplantThe first successful transplant of a circadian rhythm into a naturally non-circadian species could lead to precisely timed release of drugs and other innovative therapeutic applications. In this video, gut bacteria (E. coli) exhibit a circadian rhythm after circadian oscillators were transferred from cyanobacteria. The ‘mother cell’ at the top blinks on and off with... -
Video/AnimationSoft Robotic GloveThe soft robotic glove under development at the Wyss Institute could one day be an assistive device used for grasping objects, which could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis (ALS), incomplete spinal cord injury, or other hand impairments to regain some daily independence and control of their environment. This research is partially... -
Video/AnimationCas9: As a Transcriptional ActivatorIn this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationBioinspired Approach to Sepsis TherapyWyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard... -
Video/AnimationBone Marrow-on-a-ChipWyss Institute Founding Director Don Ingber, Postdoctoral Fellow Yu-suke Torisawa, and Researcher Catherine Spina explain how and why a they built bone marrow-on-a-chip, and how they got it to act like whole living marrow and manufacture blood cells. Credit: Wyss Institute at Harvard University -
Video/AnimationTough GelA team at the Wyss Institute is honing a tough, rubbery hydrogel initially developed at Harvards School of Engineering and Applied Sciences. The gel is 90 percent water, yet it stretches without breaking to more than 20 times its original length and recoils like rubber, the researchers first reported in Nature in 2012. In fact,... -
Video/AnimationShrinking GelWhen the temperature rises to just below body temperature, this biocompatible gel shrinks dramatically within minutes, bringing tooth-precursor cells (green) closer together. Credit: Basma Hashmi -
Video/AnimationBioprinting: Building in Blood VesselsBuilding in blood vessels. Then they addressed a big challenge in tissue engineering: embedding 3D vascular networks. They developed a ‘fugitive’ ink that can easily be printed, then suctioned off to create open microchannels that can then be populated with blood-vessel-lining cells to allow blood to flow. Read more: wyss.harvard.edu/viewpressrelease/141 Credit: Wyss Institute at Harvard... -
Video/AnimationBioprinting: Building with Bio-InksBuilding with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University -
Video/AnimationBioprinting: Building Intricate StructuresBuilding intricate structures. The team first designed a custom printer that can precisely co-print multiple materials in 3D to create intricate heterogeneous patterns. Credit: Wyss Institute at Harvard University -
Video/AnimationMeTro HydrogelsAn international team led by the Wyss Institute recently used microfabrication techniques to design a new micropatterned hydrogel that shows great promise for tissue engineering — cardiac tissue in particular. It incorporates an elastic protein called tropoelastin, which is found in all elastic human tissues. The Wyss Institute’s Ali Khademhosseini discusses the research. Credit: Wyss... -
Video/AnimationLung-on-a-ChipCombining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University