Licensing Opportunities
Our most valuable disruptive technologies with real-world potential are matured through our Validation and Institute Project programs. These projects represent a subset of Wyss Institute technologies currently available for licensing. These technologies have been considerably de-risked by our Advanced Technology and Business Development teams and continue to be refined to advance their near-term translation into commercial products that will transform medicine and create a more sustainable world.
Explore Featured Projects
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Featured Project
Injectable Hydrogel Adhesive for Improved Muscle RegenerationA super-strong, stretchy, and self-healing biomaterial that adheres to muscles and helps them heal faster after injury. -
Validation Project
DNA Nanoswitch Calipers for Single-Molecule ProteomicsDNA nanoswitch calipers are a first-of-their-kind research tool that leverage DNA’s unique molecular qualities to study post-translational modifications on proteins to unlock a new frontier of medicine. -
Institute Project
DoriVac: DNA Origami-Based Vaccines for Combination ImmunotherapyPersonalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens. -
Featured Project
Instrument-Free Molecular DiagnosticsA synthetic biology-based molecular diagnostics platform that enables the creation of low-cost, highly accurate tests for non-clinical settings. -
Validation Project
Metabolically Labeled CAR-T Cells Against CancerThrough a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies. -
Validation Project
AminoX: Making Better Protein Drugs, Quicker and CheaperAminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition. -
Validation Project
Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from AntibioticseLBP is a safe and cost-effective therapeutic for patients treated with beta-lactam antibiotics that safeguards against the loss of health-essential microbes while preventing the development and spread of antibiotic resistance. -
Validation Project
MyoExo: Wearable Muscle-Centric Sensors for Improved Assessment of Neurological DisordersMyoExo is a diagnostic technology based on strain sensors that can accurately detect muscle rigidity in patients with Parkinson’s disease and other neurological disorders. Data obtained with the device continuously from patients could improve the monitoring of treatments, and therapeutic interventions. -
Validation Project
Ichor: Reversing AgingIchor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health. -
Institute Project
ReConstruct: Vascularized Tissue for Breast Reconstruction and AugmentationReConstruct is a platform for growing, vascularizing, and implanting patient-derived tissues that enable safer breast reconstruction after cancer surgery. -
Validation Project
NodeTX: Growing Lymph Nodes to Treat CancerNodeTX is a novel immunotherapy that leverages the human body's innate ability to grow lymph nodes to fight tumors. -
Validation Project
Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease DiagnosticsThis nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers. -
Validation Project
HydroPEF: Portable Off-the-Grid Water PurificationThe Problem Globally, more than 2 billion people are forced to use a drinking water source that is contaminated with bacteria, parasites, and other pathogens, and an estimated 502,000 people die each year from diarrhea as a result of unsafe water. While a majority of the world has access to improved water sources, many are... -
Validation Project
Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious DiseaseOur novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains. -
Featured Project
Paper-Based DiagnosticsWith the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient... -
Featured Project
Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and MoreMacrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more. -
Featured Project
Catalytic Materials: Cheaper, Better Air Purification for a Healthier WorldOur catalytic materials are inspired by the nanostructure of butterfly wings and enable affordable air purification for a variety of applications. -
Featured Project
eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable DiagnosticsHandheld electrochemical sensors have revolutionized at-home medical testing for diabetics, but they have not yet been successfully applied to diagnosing other conditions. These sensors are based on the activity of an enzyme, and there are only a limited number of enzymes that can be used to detect biomarkers of human disease. An alternative, much more... -
Featured Project
DNA Nanostructures for Drug DeliveryResearchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program... -
Validation Project
DNA Nanoswitches: "Lab-on-a-Molecule” Drug DiscoveryThe Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions. -
Featured Project
Extracellular Vesicles for Biomarker DetectionA non-invasive method to identify biomarkers of disease across cell types and develop diagnostics and monitoring systems. -
Validation Project
Lactation Biologics: Increasing Milk Production for Healthier BabiesLactation Biologics is developing a long-lasting, self-injectable treatment to help nursing mothers feed their babies naturally, helping them get the best nutrition possible in the face of climate disasters and supply chain disruptions. -
Validation Project
OvaVasc: Enhanced Ovarian Tissue Engraftment for FertilityNearly 80% of women who survive cancer go on to struggle with fertility. Our team is developing an innovative approach using ovarian tissue cryopreservation: freezing and storing ovarian tissue to preserve fertility potential. By combining patient-derived cells and innovative techniques, we are accelerating tissue engraftment, boosting pregnancy rates, and preserving vital ovarian function. Our multidisciplinary...