Licensing Opportunities
Our most valuable disruptive technologies with real-world potential are matured through our Validation and Institute Project programs. These projects represent a subset of Wyss Institute technologies currently available for licensing. These technologies have been considerably de-risked by our Advanced Technology and Business Development teams and continue to be refined to advance their near-term translation into commercial products that will transform medicine and create a more sustainable world.
Explore Featured Projects
-
Institute Project
ReConstruct: Vascularized tissue for breast reconstructionReConstruct is a platform for growing, vascularizing, and implanting patient-derived tissues that enable safer breast reconstruction after cancer surgery. -
Validation Project
AminoX: Making Biologics Safer with Synthetic Biology and Advanced ChemistryAminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition. -
Validation Project
HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene TherapiesThe HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies. -
Validation Project
Plastivores: Plastic-Degrading Super-Microbes and EnzymesThe Plastic Degradation project identifies microbes from natural sources that have a low-level ability to degrade multiple types of plastic. In the laboratory, with the help of synthetic biology, those microbes then are evolved into much more effective plastic-eating microbes that, in the future, could be globally deployed to decompose plastic waste. -
Validation Project
DNA Nanoswitches: "Lab-on-a-Molecule” Drug DiscoveryThe Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions. -
Validation Project
Pancreatitis Tx: An Engineered Protein Treatment for PancreatitisFirst disease-modifying therapy that can be systemically applied to safely and effectively treat patients with different forms of pancreatitis. -
Validation Project
FeCILL: Targeted Treatment for Severe Fungal InfectionsFeCILL is novel delivery vehicle for antifungal drugs that targets them right to the infection site and reduces harmful side effects in patients with severe fungal infections. -
Validation Project
Ichor: Reversing AgingIchor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health. -
Validation Project
Metabolically Labeled CAR-T Cells Against CancerThrough a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies. -
Validation Project
Sparkle: Instant Biosensors for Real-Time ImagingSparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses. -
Validation Project
MyoExo: Smart Wearable Sensors for Parkinson’s DiseaseMyoExo is a wearable, fabric-based device with integrated smart sensors that aims to accurately monitor the primary signs of Parkinson’s Disease over time, improving diagnosis and treatment. -
Validation Project
DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based VaccinesPersonalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens. -
Validation Project
cSNAP: Eco-Friendly Air ConditioningOur eco-friendly air conditioning technology is a low-carbon-footprint evaporative cooling system that reduces indoor air temperature without adding humidity. -
Validation Project
Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from AntibioticseLBP is a safe and cost-effective therapeutic for patients treated with beta-lactam antibiotics that safeguards against the loss of health-essential microbes while preventing the development and spread of antibiotic resistance. -
Validation Project
SomaCode: Getting Cell Therapies Where They Need to GoSomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective. -
Validation Project
CircaVent: A Drug Discovery Platform for Mental Health ConditionsCircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder. -
Featured Project
Origami-Inspired Radiant Cooling for Improved Thermal HealthOrigami-inspired Radiant Cooling devices for a broad range of building interiors use microfluidic water-circuits and foldable designs that increase their surface area to achieve more effective cooling. -
Validation Project
Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease DiagnosticsThis nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers. -
Institute Project
MRBL: Next-Generation Gene Therapy for Molecular Skin RejuvenationThe next-generation gene therapy for molecular skin rejuvenation combines a comprehensive target gene prediction with a novel transdermal delivery approach for therapeutic adenovirus-associated viruses. The platform targets monogenic disease indications in the skin, and extends the same targets to the treatment of common skin aging conditions. -
Validation Project
Tough Gel Adhesives for Wound HealingA Band-Aid® adhesive bandage is an effective treatment for stopping external bleeding from skin wounds, but an equally viable option for internal bleeding does not yet exist. Surgical glues are often used inside the body instead of traditional wound closure techniques like stitches, staples, and clips because they reduce the patient’s time in the hospital... -
Validation Project
Immunostimulatory RNA Therapeutic for Treatment of Infectious Disease and CancerOur novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains. -
Validation Project
Bone Marrow-Like Scaffolds for Accelerating Immune ReconstitutionAn implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment. -
Validation Project
Single-Cell Encapsulation for Improved Cell TherapiesThe Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system.... -
Institute Project
Circe: Transforming Greenhouse Gases into Biodegradable ProductsCirce is a platform technology that uses engineered microbes to produce valuable, biodegradable synthetic polymers from greenhouse gases, minimizing the environmental impact of manufacturing. Potential applications include biodegradable plastics and packaging, energy-efficient agriculture, clean personal care products, and more. -
Validation Project
DNA Data StorageThe genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable... -
Validation Project
Biomaterial Scaffolds for T Cell ExpansionImmunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying...