Licensing Opportunities
Our most valuable disruptive technologies with real-world potential are matured through our Validation and Institute Project programs. These projects represent a subset of Wyss Institute technologies currently available for licensing. These technologies have been considerably de-risked by our Advanced Technology and Business Development teams and continue to be refined to advance their near-term translation into commercial products that will transform medicine and create a more sustainable world.
Explore Featured Projects
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Validation Project
Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from AntibioticseLBP is a safe and cost-effective therapeutic for patients treated with beta-lactam antibiotics that safeguards against the loss of health-essential microbes while preventing the development and spread of antibiotic resistance. -
Validation Project
SomaCode: Getting cell therapies where they need to goSomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective. -
Validation Project
MyoExo: Smart Wearable Sensors for Parkinson’s DiseaseMyoExo is a wearable, fabric-based device with integrated smart sensors that aims to accurately monitor the primary signs of Parkinson’s Disease over time, improving diagnosis and treatment. -
Validation Project
CircaVent: A Drug Discovery Platform for Mental Health ConditionsCircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder. -
Featured Project
Origami-Inspired Radiant Cooling for Improved Thermal HealthOrigami-inspired Radiant Cooling devices for a broad range of building interiors use microfluidic water-circuits and foldable designs that increase their surface area to achieve more effective cooling. -
Validation Project
Crisscross Nanoseed Detection: Nanotechnology-Powered Infectious Disease DiagnosticsThis nanotech-based diagnostic platform uses a unique nucleation mechanism that assembles a DNA "nanoseed" in the presence of a pathogen-derived biomarker that then is amplified within 15 minutes to create a signal for easy detection. It is highly robust, and cost-effective, and can be adapted to detect a variety of biomarkers. -
Featured Project
wFDCF Face Masks: A Wearable COVID-19 DiagnosticThe Problem The COVID-19 pandemic has made it starkly clear that the world lacks rapid, accurate diagnostic tests for pathogens. When patients arrive in a medical facility for treatment, the triage process is hindered by diagnostic tests that are inaccurate or take a long time to produce results. In addition, patients who are asymptomatic and... -
Institute Project
MRBL: Next-Generation Gene Therapy for Molecular Skin RejuvenationThe next-generation gene therapy for molecular skin rejuvenation combines a comprehensive target gene prediction with a novel transdermal delivery approach for therapeutic adenovirus-associated viruses. The platform targets monogenic disease indications in the skin, and extends the same targets to the treatment of common skin aging conditions. -
Featured Project
Rapid Metabolite-Sensing System for Blood LactateIn emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also... -
Featured Project
DNA Nanotechnology Tools: From Design to ApplicationsA suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures. -
Validation Project
Bone Marrow-Like Scaffolds for Accelerating Immune ReconstitutionAn implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment. -
Validation Project
cold-SNAP: Eco-Friendly Air ConditioningAs average global temperatures steadily climb, the worldwide demand for air conditioning is expected to triple by 2050. Conventional air conditioners, while now cheap to manufacture, still rely on low-efficiency mechanical vapor compression to cool and dehumidify air, making them one of the largest consumers of energy in industrialized countries. An alternative cooling method called... -
Validation Project
Single-Cell Encapsulation for Improved Cell TherapiesMesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system. Efforts to... -
Institute Project
Circe: Transforming Greenhouse Gases into Biodegradable ProductsCirce is a platform technology that uses engineered microbes to produce valuable, biodegradable synthetic polymers from greenhouse gases, minimizing the environmental impact of manufacturing. Potential applications include biodegradable plastics and packaging, energy-efficient agriculture, clean personal care products, and more. -
Validation Project
DNA Data StorageThe genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable... -
Validation Project
AquaPulse: Portable Off-the-Grid Water PurificationGlobally, more than 2 billion people are forced to use a drinking water source that is contaminated with bacteria, parasites, and other pathogens, and an estimated 502,000 people die each year from diarrhea as a result of unsafe water. While a majority of the world has access to improved water sources, many are often contaminated;... -
Validation Project
abbieSense: Anaphylaxis DiagnosticThe molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately... -
Validation Project
Biomaterial Scaffolds for T Cell ExpansionImmunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying... -
Validation Project
Tough Gel Adhesives for Wound HealingA Band-Aid® adhesive bandage is an effective treatment for stopping external bleeding from skin wounds, but an equally viable option for internal bleeding does not yet exist. Surgical glues are often used inside the body instead of traditional wound closure techniques like stitches, staples, and clips because they reduce the patient’s time in the hospital... -
Institute Project
JetValve for Heart RegenerationThe human heart beats approximately 35 million times every year, pumping blood into the circulation via four different heart valves. In more than four million people each year, heart valves fail for different reasons, including birth defects, age-related deteriorations and infections. At present, clinicians use either artificial prostheses or fixed animal and cadaver-sourced tissue to...