Technology Area: Organs on Chips

Technologies 9

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• Blood Clot Dx
  An ultra-sensitive triage test that identifies patients at risk for blood clots before they happen, enabling proactive treatment to reduce complications and deaths across a wide range of conditions.
• Ropirio: Novel Treatments Targeting the Lymphatic System
  Ropirio is commercializing the world’s first drug that directly targets and reactivates lymph vessels, a portfolio of other lymph-targeting small molecules, and a preclinical platform for discovering more.
• Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
  Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering.
• Sugar-to-Fiber Enzyme for Healthier Food
  In collaboration with Kraft Heinz, our sugar-to-fiber product can convert sugar in food products into prebiotic fiber in the human gut, reducing the amount of sugar absorbed into the bloodstream without altering the amount of sugar in existing food product recipes.
• 3D Bioprinting of Living Tissues
    The Problem There is a severe shortage of human organs for people who need transplants due to injury or disease: more than 103,000 people are on the waiting list for organs in the US, and it’s estimated that 17 people die waiting for an organ transplant every day. Growing full organs from living human...
• Human Organs-on-Chips
  Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.

Collaborations 1

• Kraft Heinz Partnership
  The Kraft Heinz company approached the Wyss Institute for help to achieve its ambitious goal to make its food products healthier, resulting in a novel technology that is ripe for commercialization.

News 148

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• Community
  
  Ernest Aguinam on understanding the immune system to help patients with radiation injury and chronic Lyme
  September 29, 2026
• Research Spotlights
  
  Accelerating biomedical innovation with AI through collaborative iteration
  August 6, 2026
• Press Release
  
  Recapitulating intramuscular vaccination with mRNA vaccines in patient-specific Lymphoid Organ Chips
  July 17, 2026

Multimedia 47

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  Video/Animation
  Cutting to the Case: Don Ingber
  Don Ingber, M.D., Ph.D., is the Founding Director of Harvard University’s Wyss Institute for Biologically Inspired Engineering and a pioneer of organ-on-a-chip technology. In this episode of Cutting to the Case, Ingber and host Cameron Sabet discuss how he helped create organs-on-chips, what these systems can teach us that traditional models cannot, and how biologically...

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  Audio/Podcast
  Next-Gen Toxicology: Inside the Organ Chip Revolution with Donald Ingber
  In this episode of ToxChats, hosts Lauren Walker and Sarah Benjamin sit down with the groundbreaking Donald Ingber—visionary scientist, engineer, and Founding Director of the Wyss Institute. Ingber shares how his unique path through medicine, biology, and design converged to spark breakthroughs such as human Organ Chips—systems that are redefining toxicology, drug development, and disease...

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  Video/Animation
  20-ish Questions with Donald E. Ingber
  20-ish Questions shows a different side of Wyss Institute faculty, touching on aspects of their personal life, hobbies, interests, as well as their research. This round follows Donald E. Ingber, the Founding Director and a Core Faculty member at the Wyss Institute. He is also the Judah Folkman Professor of Vascular Biology at Harvard Medical...

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  Video/Animation
  AVATARs for Astronaut Health Are Heading to Space!
  NASA’s AVATAR experiment is flying aboard Artemis II to study how deep space affects human health. Using Organ Chips containing astronaut cells, Emulate and Wyss Institute researchers will examine how radiation and microgravity impact human tissue. This research will help inform medical strategies for future long-duration missions to Mars and beyond. The findings could also...

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  Audio/Podcast
  Organs on Chips: Using Science, Art, and Design to Understand the Human Body – Talking About Blood
  In this episode, Wyss Founding Director Don Ingber, M.D., Ph.D., talks with Helen Osborne about: How organ-on-chip and “human body on chips” technologies are built and how they realistically mimic human organ function by combining living cells, blood flow, and mechanical forces like breathing and stretch; The implications of these chips for hematology and clinical...

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  Video/Animation
  Reimagining a World Without Terminal Illness
  As he battles metastatic skin cancer, Wyss Scientific Instrument maker John Caramanica is more motivated than ever to do his part in fabricating technologies to improve the health of others and our planet. Credit: Wyss Institute at Harvard University