Discipline: Mechanobiology

Technologies 18

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• MyoExo: Wearable Muscle-Centric Sensors for Improved Assessment of Neurological Disorders
  MyoExo is a diagnostic technology based on strain sensors that can accurately detect muscle rigidity in patients with Parkinson’s disease and other neurological disorders. Data obtained with the device continuously from patients could improve the monitoring of treatments, and therapeutic interventions.
• Wearable Technology for True Movement Quantification
  WurQ combines wearable sensors, with deep learning and signal processing algorithms, to assess the amount, quality, and intensity of functional movements and strength training activities. This quantitative data enables feedback, guidance, and gamification at scale to improve users fitness routines and health.
• Single-Cell Encapsulation for Improved Cell Therapies
  The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....
• Soft Robotic Glove for Neuromuscular Rehabilitation
  The soft robotic glove helps restore lost hand function in patients with neurological conditions using inflatable chambers that gently bend and straighten the fingers repeatedly. Wyss startup Imago Rehab launched in 2021 to commercialize this technology for at-home rehabilitation of stroke survivors, and aims to expand its offerings into other areas of rehabilitation.
• PhonoGraft^TM: Biomimetic Hearing-restoration Technology
  PhonoGraft is an eardrum-regenerating device that enables better and longer-lasting eardrum reconstruction, reducing the need for invasive surgeries and minimizing the risk of long-term hearing loss. Wyss startup Beacon Bio was acquired by Desktop Health, a healthcare business within Desktop Metal, Inc. which is further developing this technology towards commercialization with the former Wyss startup team leading the way.
• milliDelta: Millimeter-Scale Delta Robot
  Delta robots are deployed in many industrial processes, including pick-and-place assemblies, machining, welding, and food packaging. Three individually controlled lightweight arms enable fast and accurate motion of an output platform in three directions. Roboticists have reduced the size of Delta robots for tasks in limited workspaces, but so far, using conventional manufacturing techniques and components,...

Collaborations 1

• Wyss Brain Targeting Program
  Advancing brain delivery approaches that enable more safe and effective brain-targeted therapeutics.

News 141

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• Press Release
  
  Wyss Institute promotes Natalie Artzi to its Core Faculty and appoints Di Feng as an Associate Faculty member
  August 12, 2024
• Press Release
  
  Human cervix modeled in microfluidic organ chip fills key women’s health gap
  May 31, 2024
• Press Release
  
  Expanding a lymph node, boosting a vaccine
  May 6, 2024

Multimedia 52

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  Video/Animation
  Bridging science, engineering, and art: from mechanobiology to Human Organs-on-Chips
  In this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human...

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  Audio/Podcast
  Of Mice and Massage with Dr. Bo Ri Seo
  You know those people who say you can’t change tissue? Well Wyss Postdoctoral Fellow Bo Ri Seo explains otherwise on this episode of BodyTalk.  She is the lead writer on an exciting paper. Dr. Bo Ri Seo is a biomedical engineer who has been studying mechanobiology and mechanotherapy to develop therapeutic strategies for cancer and...

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  Video/Animation
  PhonoGraft: Programming the eardrum to repair itself
  Eardrum perforations are a widespread problem affecting millions worldwide. Current standard of care is invasive, involves harvesting an autologous tissue to patch the eardrum, and often requires to revision surgeries, while hearing outcomes remain unsatisfying. What if we could program the eardrum to repair itself after injury? Researchers at the Wyss Institute, Massachusetts Eye and...

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  Video/Animation
  The Human Mind and Gait Control
  Researchers study how our brains adjust to changes in our walking strides, gaining insights that could be used to develop better physical rehabilitation programs. Credit: Wyss Institute

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  Video/Animation
  Hip-only Soft Exosuit for both Walking and Running
  This video demonstrates the use of the hip-assisting exosuit in different natural environments, and shows how the robotic device senses changes in the gait-specific vertical movements of the center of mass during walking and running to rapidly adjust its actuation. Credit: Wyss Institute at Harvard University

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  Video/Animation
  Kidney Organiods: Flow-Enhanced Vascularization and Maturation In Vitro
  This video explains how the collaborative project created vascularized kidney organoids and how they advance the field of tissue engineering. Credit: Wyss Institute at Harvard University.