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Video/AnimationInnovating Diagnostics to Improve Clinical Care and Patient OutcomesGuest speaker, Sarah-Beth Perullo, shares the immense difficulty she faced in obtaining a diagnosis for her mysterious symptoms. Her story is a sobering reminder of how frequent patient symptoms are dismissed in the medical field. Credit: Wyss Institute at Harvard University -
Video/AnimationWorld of OMICs w/ David Walt & Mike Snyder – BIOS RoundtableThis is a roundtable discussion on the world of OMICs with Wyss Core Faculty member David Walt and Mike Snyder of Stanford University presented by BIOS. David Walt is a Hansjörg Wyss Professor of Biologically Inspired Engineering at Harvard Medical School, a Professor of Pathology at Brigham and Women’s Hospital, a Core Faculty member at... -
Video/AnimationHow can we restore mobility to the sick and injured?Researchers at the Wyss Institute are working to improve treatment outcomes for patients suffering from reduced mobility. This video focuses on two platform technologies that could improve the quality of life for these patients: stochastic resonance and wearable soft robotics. Credit: Wyss Institute at Harvard University -
Video/AnimationHow can we get diagnostics to patients faster?The Wyss Diagnostics Accelerator (DxA) is an initiative to enable the fast creation of diagnostic technologies to solve high-value clinical problems through deep collaborations driven by unmet diagnostic needs. Credit: Wyss Institute at Harvard University -
Video/AnimationReimagine the World – Volume 2 – Diagnostics AcceleratorTwo clinicians collaborating with the Wyss Diagnostics Accelerator (DxA), Lise Johnson and Craig Hersh, as well as two members of the Wyss DxA Industrial Partnership Program, Nell Meosky Luo and Andy Levin, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. Credit: Wyss... -
Video/AnimationWyss Diagnostics Accelerator – The Industrial Participant ProgramThe Industrial Participant Program (IPP) is a collaboration hub between healthcare testing companies and the scientific and clinical community within the Wyss ecosystem, driven by the Wyss Diagnostics Accelerator (DxA). Members of the IPP share the common goal of fast-tracking diagnostic technologies to meet unmet, critical needs. Credit: Wyss Institute at Harvard University -
Video/AnimationReimagining Health Equity: Wyss Diagnostics AcceleratorWith the Wyss Diagnostics Accelerator (DxA), we’re reimagining health equity by accelerating the development and deployment of needed diagnostics in all settings, particularly in low-resource settings, by fostering deep collaborations driven by unmet needs. Credit: Wyss Institute at Harvard University -
Video/AnimationReimagining Diagnostics for His Mom: Pawan JollyPawan Jolly is a Senior Staff Scientist leading the Sensors team to help develop better diagnostics for various illnesses and allergies. He also serves as the technology lead for the Wyss Diagnostics Accelerator. In this video, he shares a heartfelt personal story about his mom who suffers from severe allergies and how he would Reimagine... -
Video/AnimationReimagine the World: Volume 1Four Wyss Institute scientists, Mariana Garcia-Corral, Pawan Jolly, Megan Sperry, and Mike Super, share how they would Reimagine the World and the personal stories that fuel their passion for the work they are doing. We’d love to hear how you would Reimagine the World! Please visit the following link to share your ideas: https://wyss.typeform.com/to/o9xM7cG1 Credit:... -
Audio/PodcastBIOS Podcast – Accelerating Diagnostics Innovation with David Walt – Professor at Harvard, Core Faculty member at the Wyss InstituteDavid Walt is the Hansjörg Wyss Professor of Bioinspired Engineering at Harvard Medical School, Professor of Pathology at Harvard Medical School & Brigham and Women’s Hospital, Core Faculty Member of the Wyss Institute at Harvard University, Associate Member at the Broad Institute, Howard Hughes Medical Institute Professor, and is co-Director of the Mass General Brigham... -
Video/Animation2021 Kabiller Prize in Nanoscience and NanomedicineDavid R. Walt, a Wyss Core Faculty member, member of the faculty at Harvard Medical School in the Department of Pathology, and a Howard Hughes Medical Institute Professor, is the winner of the 2021 Kabiller Prize in Nanoscience and Nanomedicine, the world’s largest monetary award for outstanding achievement in the field of nanotechnology and its... -
Video/AnimationeToehold: an RNA-detecting control element for use in RNA therapeutics, diagnostics and cell therapiesThis animation shows an example of an eToehold that detects and signals the presence of a specific viral RNA in a human cell. After the virus has injected its RNA into a host cell, the RNA acts as a “trigger RNA” by binding to a complementary sequence within the eToehold specifically engineered for its detection.... -
Video/AnimationBeating Back the Coronavirus – Nasal swabsEarly in the COVID-19 pandemic, Nasopharyngeal swabs or nasal swabs, used to collect mucus samples to test for the SARS-CoV-2 virus, were in short supply. This created a bottleneck in diagnostics, hampering our ability to control the pandemic. To respond to this need, an interdisciplinary team at the Wyss Institute and Harvard Medical School collaborated... -
Video/AnimationInnovation Showcase – Wyss Institute: Wearable Technology with BiosensorsJay Sugarman talks with Peter Nguyen Ph.D., Luis Soenksen, Ph.D., and Nina Donghia–all of whom are associated with the Wyss Institute for Biologically Inspired Engineering at Harvard University. They’re on Innovation Showcase to inform viewers about the groundbreaking research they and their colleagues have been involved with related to the development of wearable technology as... -
Video/AnimationmiSherlock – Detecting COVID-19 Variants from SalivaDespite increasing vaccination rates, new, more-infectious variants of SARS-CoV-2 could prolong the COVID-19 pandemic. Researchers at the Wyss Institute at Harvard University and MIT have created a low-cost, CRISPR-based diagnostic platform that can detect SARS-CoV-2 variants in a patient’s saliva without the need for any additional equipment. The team hopes their device will enable more... -
Audio/PodcastTalking Biotech: COVID-19 Detection Masks and WearablesCOVID-19 is the spectrum of pathologies caused by the SARS-CoV2 virus. While the pandemic moves well into its second year, the importance of detection in populations cannot be overstated. However, testing methods typically include visiting testing centers, and it is hard to find a test that is both rapid and precise. Wyss Research Scientist Dr.... -
Video/AnimationBeating Back the Coronavirus – COVID-19 detecting face maskUsing freeze-dried cell free reactions and CRISPR-based biosensors, researchers at the Wyss Institute and M.I.T. have created a face mask that can detect the SARS-CoV-2 virus in a wearer’s breath in under 90 minutes. Such a mask would allow medical professionals to quickly identify COVID-19 patients and begin effective treatments. This facemask is a proof-of-concept... -
Video/AnimationWearable Synthetic Biology – Clothing that can detect pathogens and toxinsWhat if we could create clothing that harnesses synthetic biology to detect the wearer’s exposure to toxins and pathogens? A team of researchers at the Wyss Institute and M.I.T. did just that byembedding freeze-dried, synthetic biology-based sensors into flexible materials and textiles. These sensors can detect pathogens such as the SARS-CoV-2 virus and toxins such... -
Audio/PodcastHarnessing the Power of Artificial Intelligence & Synthetic Biology To Usher In A New Age of Drug Discovery: Jim Collins3 Takeaways features intimate conversations and insights from the world’s best thinkers, business leaders, writers, politicians, scientists, and other newsmakers. Each episode ends with the 3 key takeaways the leading figure has learned over their career. It’s hosted by Lynn Thoman. James Collins, Wyss Core Faculty member and co-inventor of the technology behind Covid vaccines,... -
Video/AnimationNature Can Help Us Prepare for the Next PandemicResiliency, redundancy, adaptability: COVID-19 has shown humanity that we need more of the qualities that are built into nature. See how a cat’s tongue inspired Wyss Lead Staff Engineer Richard Novak to create a novel nasal swab design to aid in COVID-19 diagnostics. -
Audio/PodcastResearching Biosensors with Dr. Pawan JollyPoint of Care Medical Devices are the future! Pawan Jolly, Ph.D., Senior Staff Scientist at The Wyss Institute for Biologically Inspired Engineering at Harvard University talks with Jonah and Aryan of the Beyond the Books podcast about his research in the biosensor and medical device arena. They ask him about his latest COVID-19 focused project,... -
Video/AnimationUsing deep learning to detect cancerous skin lesionsMelanoma is a very severe cancer that is often diagnosed too late to save patients’ lives, and most people do not regularly visit a dermatologist for skin exams. Early-stage identification of suspicious pigmented lesions (SPLs), ideally by primary care providers, could lead to improved melanoma prognosis. Researchers at the Wyss Institute and MIT have developed... -
Video/AnimationeRapid: Bringing Diagnostics HomeSenior Research Scientist, Pawan Jolly, gives an overview of the eRapid Institute Project, a platform of multiplexed electrochemical sensors for fast, accurate, portable diagnostics. Credit: Wyss Institute at Harvard University -
Video/AnimationeRAPID: a Platform for Portable DiagnosticseRapid is an electrochemical sensing platform that uses a novel antifouling coating to enable low-cost, multiplexed detection of a wide range of biomolecules for diagnostics and other applications. Credit: Wyss Institute at Harvard -
Video/AnimationRapid Triage Test for Active Pulmonary TuberculosisThere’s a large unmet need for accurate, fast, and inexpensive diagnostics for active tuberculosis (ATB), which claims the lives over a million people per year. A team of researchers from the Wyss Institute for Biologically Inspired Engineering, The Broad Institute of Harvard and MIT, Brigham and Women’s Hospital (BWH), and several other collaborating institutions have... -
Audio/PodcastDisruptive: Accelerating DiagnosticsIn this episode of Disruptive, Wyss Core Faculty member David Walt discusses his lessons learned from founding successful biotech companies and how he incorporates translation-minded thinking early on into his current diagnostic research in his labs at the Wyss Institute and the Brigham and Women’s Hospital. Walt and collaborators are inventing new diagnostic tools to... -
Video/AnimationLighting up proteins with Immuno-SABERThis animation explains how Immuno-SABER uses the Primer Exchange Reaction (PER) to enable the simultaneous visualization of multiple proteins in tissues in different applications. Credit: Wyss Institute at Harvard University. -
Audio/PodcastScientists not the Science: Entrepreneur – David WaltThis podcast episode was produced for the Scientists not Science series. Physicist and active researcher Dr. Stuart Higgins speaks with David Walt about his background, from growing up on the outskirts of Detroit, through his academic career, to the key seminar he gave that got him noticed by a venture capitalist. Throughout David’s career he... -
Video/AnimationabbieSenseabbieSense is a Wyss technology that can detect histamine levels in human body fluids and determine the severity of an allergic reaction, which could help save the lives of patients with severe allergies. Credit: Wyss Institute at Harvard University -
Video/AnimationToehold Exchange ProbesThis animation explains how toehold probes consisting of a “probe strand” and a “protector strand” are assembled and how they leverage thermodynamic principles to allow the specific detection of a correct target sequence, or to prevent them from detecting a spurious target sequence that can differ from the correct target sequence by only a single... -
Video/AnimationAuto-cyclic Proximity RecordingThis video explains how “Auto-cycling Proximity Recording” works to identify pairs of nearby molecular targets and how it can be used as a tool to decipher the geometry of 3-dimensional engineered and natural molecules. Credit: Wyss Institute at Harvard University -
Video/AnimationProject ABBIEProject ABBIE is inspired by the story of Abbie Benford, who succumbed to complications related to anaphylaxis just eight days before her 16th birthday. The Wyss Institute, in collaboration with Boston Children’s Hospital, is developing a wearable, non-invasive device that could sense anaphylaxis and automatically inject epinephrine in individuals who are unable to do so... -
Video/Animation3D Printed Heart-on-a-ChipIn this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University -
Video/AnimationSmoking Human Lung Small Airway-on-a-ChipIn this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University -
Audio/PodcastDisruptive: Fluorescent In Situ SequencingDeveloped at the Wyss, FISSEQ (fluorescent in situ sequencing) is a spatial gene sequencing technology that reads and visualizes the three-dimensional coordinates of RNA and mRNAs – the working copies of genes – within whole cells and tissues. FISSEQ affords insights into biological complexity that until now have not been possible. In this episode of... -
Audio/PodcastDisruptive: Rapid, Low-Cost Detection of Zika & Future PandemicsThe rapid emergence of the Zika virus on the world stage calls for a detection system that is just as quick. In this episode of Disruptive, Wyss Core Faculty member and MIT professor Jim Collins and University of Toronto Assistant Professor Keith Pardee discuss how they developed a low cost, paper-based diagnostic platform that can... -
Audio/PodcastDisruptive: Molecular RoboticsHow can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for... -
Video/AnimationDetecting Zika: A platform for rapid, low-cost diagnosticsIn this video, a team of collaborators led by Wyss Core Faculty member James Collins discuss a low-cost, paper-based diagnostic system that they developed for detecting specific strains of the Zika virus, with the goal that it could soon be used in the field to easily screen blood, urine, or saliva samples. Credit: Wyss Institute... -
Audio/PodcastGeorge Church: Responsibility, art & science of intentional extinction, de-extinction & agingGeorge Church Responsibility, art & science of intentional extinction, de-extinction & aging Wednesday, Feb 17, 2016 ArtScience @ Le Lab Lecture Series: Art, Design, Engineering & Biology – Core Faculty from the Wyss Institute for Biologically Inspired Engineering at Harvard University discuss how the arts and design are informing the frontiers of science. ArtScience @... -
Video/AnimationSmall Airway-on-a-Chip: Modeling COPD and AsthmaDevelopment of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway... -
Video/AnimationDistributed Cell Division CounterGenetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University -
Video/AnimationGastrointestinal Re-ProgrammingIn this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University -
Video/AnimationAntibiotic EfficacyIn this video, Wyss Institute Core Faculty member James Collins and Michael Lobritz explain how antibiotics can have vastly different effects on pathogenic bacteria and suggest potential implications for improving antibiotic treatments in infected patients. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA NanoswitchesGel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most... -
Video/AnimationHuman Organs-On-ChipsWyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer... -
Video/AnimationToehold SwitchesIn this animation, Wyss Institute Postdoctoral Fellow Alex Green, Ph.D., the lead author of “Toehold Switches: De-Novo-Designed Regulators of Gene Expression”, narrates a step-by-step guide to the mechanism of the synthetic toehold switch gene regulator. Credit: Wyss Institute at Harvard University -
Video/AnimationProgrammable Paper: Advances in Synthetic BiologyWyss Institute scientists discuss the collaborative environment and team effort that led to two breakthroughs in synthetic biology that can either stand alone as distinct advances – or combine forces to create truly tantalizing potentials in diagnostics and gene therapies. Credit: Wyss Institute at Harvard University. -
Video/AnimationBioinspired Approach to Sepsis TherapyWyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard... -
Video/AnimationVirus-inspired DNA NanodevicesWyss Institute Core Faculty member William Shih and Technology Development Fellow Steven Perrault explain why DNA nanodevices need protection inside the body, and how a viral-inspired strategy helps protect them. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA CagesTo create supersharp images of their cage-shaped DNA polyhedra, the scientists used DNA-PAINT, a microscopy method that uses short strands of DNA (yellow) labeled with a fluorescent chemical (green) to bind and release partner strands on polyhedra corners, causing them to blink. The blinking corners reveal the shape of structures far too small to be... -
Video/AnimationFluorescent in situ SequencingIn this video, George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School, explains how fluorescent in situ sequencing could lead to new diagnostics that spot the earliest signs of disease, and how it could help reveal how neurons in the brain connect and function. Credit:... -
Video/AnimationNew coating turns glass into superglassA transparent new coating makes ordinary glass tough, ultraslippery, and self-cleaning. The coating is based on SLIPS — the world’s slipperiest synthetic substance. Here, a droplet of dyed octane quickly beads up and rolls off a watch glass with the new coating. To learn more, go to Credit: Wyss Institute at Harvard University -
Video/AnimationNeuroAssessA team at Harvard’s Wyss Institute and Beth Israel Deaconess have developed a computer tablet application that could rapidly and quantitatively assess neuromuscular performance. Credit: Wyss Institute at Harvard University -
Video/AnimationVibrating Mattress: Preventing Infant ApneaWhat if we could prevent infant apnea? Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Sepsis DiagnosticWhat if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Organs-on-a-ChipWhat if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each...