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Pathogen Capture Technology for Infectious Disease Therapeutics and Diagnostics
Microbial contamination is the cause of life-threatening cases of sepsis, meningitis and multiple other infectious diseases that are a major cause of death world-wide. Equally prevalent are pathogenic contaminants in our environment, food, and manufacturing processes. In each case, the presence of microbial contaminants must be confirmed, and when they are found, they need to...
Human Organs-on-Chips
Clinical studies take years to complete and testing a single compound can cost more than $2 billion. Meanwhile, innumerable animal lives are lost, and the process often fails to predict human responses because traditional animal models often do not accurately mimic human pathophysiology. For these reasons, there is a broad need for alternative ways to...
SLIPS (Slippery Liquid-Infused Porous Surfaces)
The need for an inexpensive, super-repellent surface cuts across a vast swath of societal sectors—from refrigeration and architecture, to medical devices and consumer products. Most state-of-the-art liquid repellent surfaces designed in the last decade are modeled after lotus leaves, which are extremely hydrophobic due to their rough, waxy surface and the physics of their natural...
Paper-based synthetic gene networks as a new diagnostic approach
With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient...
Microfluidic Hemostasis Monitor
The body’s ability to stop bleeding, also known as hemostasis, is critical for survival. For patients with blood clotting disorders, medical conditions requiring the use of anticoagulation or antiplatelet drugs, or who require treatment with extracorporeal devices that circulate their blood outside of the body, it is essential that care providers can rapidly monitor their...
Pop-Up MEMS
Recent decades have seen rapid development in the manufacture of microelectromechanical systems (MEMS) at the micrometer scale, mostly based on silicon wafer processing techniques, with characteristic length scales of millimeters to nanometers. However, standard MEMS techniques are often inappropriate for producing machines with complex 3D topologies and varied constituent materials at the mesoscale, at sizes...

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