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Technologies / Diagnostics

Diagnostics

Molecular biomarkers hold great promise for diagnosing diseases at earlier, more treatable stages, but their full potential has not yet been realized. We are changing that paradigm by combining powerful molecular biology, chemistry, and engineering tools, for example, enabling biomarker detection down to the single-molecule level, both in the lab and at the point-of-care.

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Rapid Metabolite-Sensing System for Blood Lactate
Rapid Metabolite-Sensing System for Blood Lactate

In emergency medicine, blood lactate levels are a reliable real-time indicator of the severity and mortality risk of conditions that occur as a result of poor blood circulation and oxygen supply to organs and tissues (hypoperfusion), such as in patients with sepsis, cardiac arrest, stroke, major trauma, cystic fibrosis and other conditions. Lactate levels also...

DNA Nanotechnology Tools: From Design to Applications
DNA Nanotechnology Tools: From Design to Applications

DNA nanostructures with their potential for cell and tissue permeability, biocompatibility, and high programmability at the nanoscale level are promising candidates as new types of drug delivery vehicles, highly specific diagnostic devices, and tools to decipher how biomolecules dynamically change their shapes, and interact with each other and with candidate drugs. Wyss Institute researchers are...

eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics
eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics

Handheld electrochemical sensors have revolutionized at-home medical testing for diabetics, but they have not yet been successfully applied to diagnosing other conditions. These sensors are based on the activity of an enzyme, and there are only a limited number of enzymes that can be used to detect biomarkers of human disease. An alternative, much more...

Brain Targeting Program: Shuttles for Brain Delivery of Therapeutics and Diagnostics
Brain Targeting Program: Shuttles for Brain Delivery of Therapeutics and Diagnostics

In its Brain Targeting Program, a Wyss team led by Founding Director Donald Ingber, M.D., Ph.D. and Staff Program Lead James Gorman, M.D., Ph.D. is developing improved approaches to target drugs and diagnostics to the brain. Leveraging the human blood-brain barrier (BBB) Chip technology developed by Ingber’s team, combined with advanced antibody R&D capabilities, the...

abbieSense: Anaphylaxis Diagnostic
abbieSense: Anaphylaxis Diagnostic

The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...

Toehold Switches for Synthetic Biology
Toehold Switches for Synthetic Biology

The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...

Project Abbie
Project Abbie

Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications, and insect bites. Every three minutes, a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug epinephrine, as soon as an attack...

Paper-Based Diagnostics
Paper-Based Diagnostics

With the imminent threat of new pandemics and frequent disease outbreaks exemplified by the recent Ebola and Zika epidemics, there is a growing need for low-cost, easily deployable and simple-to-use diagnostic tools. The Wyss Institute has developed paper-based synthetic gene networks as a next generation diagnostic technology for use in global healthcare crises and patient...

Microfluidic Hemostasis Monitor
Microfluidic Hemostasis Monitor

The body’s ability to stop bleeding, also known as hemostasis, is critical for survival. For patients with blood clotting disorders, medical conditions requiring the use of anticoagulation or antiplatelet drugs, or who require treatment with extracorporeal devices that circulate their blood outside of the body, it is essential that care providers can rapidly monitor their...

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