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Audio/PodcastSeqVerify: A New Easily Accessible Tool for Comprehensive Cell Line Quality Assessment – The Stem Cell ReportDuring the last decade, advances in genome editing and pluripotent stem cell (PSC) culture have let researchers generate edited PSC lines to study a wide variety of biological questions. However, abnormalities in cell lines such as aneuploidy, mutations, on-target and off-target editing errors, and microbial contamination can arise during PSC culture or due to undesired... -
Video/AnimationAminoX: Making Better Protein Drugs, Quicker and CheaperA synthetic biology and advanced chemistry platform that efficiently incorporates non-standard amino acids by hacking the ubiquitous protein synthesis process. Credit: Wyss Institute at Harvard University -
Video/AnimationAtlantic Health Research Spotlight: Finding Balance in Bipolar Disorder Through Drug Prediction and Organoid-Based Drug ScreeningInnovation has disrupted care as we know it. Challenges with access, complex diseases, and care delivery persist, but so do areas of opportunity for emerging tech and discoveries. The Atlantic explored gene editing, artificial intelligence, climate change, weight-loss and diabetes treatments, and more at their Annual Health Summit. The Wyss’ Director of Synthetic Biology, Jenny... -
Video/AnimationReimagine the World – Volume 3 – Northpond EditionThe Wyss Institute’s alliance with Northpond Labs supports early-stage, transformative research with strong translation potential. Hear Northpond Ventures co-founders Michael Rubin and Sharon Kedar explain why they decided to partner with the Wyss, as well as the leaders of various Wyss projects and startups about how support from Northpond has helped accelerate their technologies to... -
Video/AnimationHarborSite AnimationThis animation explains how the Wyss Institute’s HarborSite genome editing technology uses highly specific and efficient recombinase enzymes and genomic safe harbors to achieve more predictable, safe, and durable gene therapies. Credit: Wyss Institute at Harvard University -
Video/AnimationEnhancing Lactation to Improve Infant and Maternal HealthLactation Biologics is developing a long-lasting, self-injectable treatment to help nursing mothers feed their babies naturally, helping them get the best nutrition possible in the face of climate disasters and supply chain disruptions. Credit: Wyss Institute at Harvard University -
Audio/PodcastIdeas to Innovation – From Lab to Life: The Transformative Power of Synthetic BiologyRapid advancements in technology and science are shaping a new era, with artificial intelligence and synthetic biology, or “syn-bio,” at the forefront. Heralded as the next big leap in science, syn-bio involves redesigning organisms for useful purposes by engineering them to have new abilities. The importance of syn-bio for people and our planet cannot be... -
Video/AnimationPeter Nguyen: Biology Engineering, Bigfoot Hunting, and Better Climate TechnologyWyss Senior Scientist Peter Nguyen received a B.S. in Biochemistry and B.A. in Philosophy from the University of Texas, his M.Bs. from the Keck Graduate Institute, and his Ph.D. in Biochemistry from Rice University. At the Wyss Institute, Peter currently works on programmable probiotics and freeze-dried cell-free manufacturing technology across multiple platforms. His research interests... -
Video/AnimationHow can we feed the world?The current agricultural methods of feeding the world are not sustainable and already have dire consequences that will worsen as the Earth’s population continues to grow. Researchers at the Wyss Institute are working on various solutions that could help provide food for our future needs with a lower environmental impact. Credit: Wyss Institute at Harvard... -
Audio/PodcastReimagining Infertility – An Interview with Christian KrammeChristian Kramme imagines a world where all people can have a child on their own time frame. Such “reproductive autonomy” is not the case today – infertility is a growing problem worldwide, and existing treatments like IVF are incredibly taxing on women’s bodies and too expensive for most of the global population to access. Listen... -
Video/AnimationAcademic Entrepreneurship w/ Bob Langer & George Church – BIOS Roundtable #4George Church is a Core Faculty member at the Wyss Institute and a Professor at Harvard University. George leads Synthetic Biology at the Wyss Institute, where he oversees the directed evolution of molecules, polymers, and whole genomes to create new tools with applications in regenerative medicine and bio-production of chemicals. Among his recent work at... -
Video/AnimationReimagining Neurodegenerative Disease Treatment for Her Grandfather: Mariana Garcia-CorralMariana Garcia-Corral is a Research Assistant studying brain organoids to help with the treatment of bipolar disorder. In this video, she shares a poignant personal story about her grandfather suffering from Lewy body dementia and how she would Reimagine a World with better neurodegenerative disease treatment. Credit: Wyss Institute at Harvard University -
Video/AnimationSomaCode: GPS for Cell TherapyJust like zip codes help drivers navigate to specific addresses using a GPS system, the molecular ‘zip codes’ identified via the SomaCode platform can be used to deliver cell therapies to their specific targets in the human body, increasing the therapies’ efficacy and reducing side effects. Credit: Wyss Institute at Harvard University -
Video/AnimationEngineering Solutions to Confront the Climate CrisisAt the Wyss Institute, we are committed to tackling this existential climate crisis and are expanding our portfolio of sustainability research projects. Join us in reimagining a more sustainable future, together. Credit: Wyss Institute at Harvard University -
Audio/PodcastXenotransplantation – The Naked Scientists Podcast with George ChurchAmidst the aftermath of COVID-19 waiting lists continue to grow for those in need of an organ transplant, whilst simultaneously in an American surgery a man receives the heart of a pig. Animal donors may be the answer to our shortage of available organs, but the procedure isn’t quite ready to become common place. Take... -
Audio/PodcastTranslating SynBio with Jim CollinsThe BIOS Podcast by Alix Ventures features experts and thought leaders in healthcare & life sciences. We bring you cutting-edge insights from executives, investors, founders, scientists, academics, and more. BIOS is a community of early stage healthcare and life sciences founders and investors. It is anchored by Alix Ventures, a San Francisco-based venture fund that invests in early stage...
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Audio/PodcastHarnessing the Power of Artificial Intelligence & Synthetic Biology To Usher In A New Age of Drug Discovery: Jim Collins3 Takeaways features intimate conversations and insights from the world’s best thinkers, business leaders, writers, politicians, scientists, and other newsmakers. Each episode ends with the 3 key takeaways the leading figure has learned over their career. It’s hosted by Lynn Thoman. James Collins, Wyss Core Faculty member and co-inventor of the technology behind Covid vaccines,...
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Video/AnimationCirce: Using Microbes to Make Biodegradable ProductsCurrent manufacturing methods release harmful greenhouse gases and pollution, and many of the products produced do not biodegrade, damaging our ecosystems even further. What if we could turn greenhouse gases into biodegradable products? Researchers at the Wyss Institute are using synthetic biology to make this a reality. Credit: Wyss Institute at Harvard University -
Video/AnimationGeorge Church in the Xchange: Curiosity-Driven Science, Technology, And SocietyIn this episode of the Xchange, we hear from George Church, a true pioneer of synthetic biology and genomics. George will share possible silver linings of the COVID-19 pandemic, draw parallels between personalized medicine and personalized learning and explore what it means to really think outside of the box. A new virtual interview series from... -
Video/AnimationEnzymatic DNA Synthesis (EDS) for Data StoragePostdoctoral Fellow, Henry Lee, presents a Wyss Institute Validation Project that is developing a sustainable, low-cost approach for writing large amounts of digital information in DNA. This could one day replace current data storage methods, which are energy intensive and use large amounts of nonrenewable resources. Credit: Wyss Institute at Harvard University -
Video/AnimationBeating Back the CoronavirusWhen the coronavirus pandemic forced Harvard University to ramp down almost all on-site operations, members of the Wyss Institute community refocused their teams, and formed new ones, in order to fight COVID-19 on its multiple fronts. These efforts include building new pieces of personal protective equipment that were delivered to frontline healthcare workers, developing new... -
Video/AnimationImproving Canine HealthspanA Wyss Institute technology that can treat multiple age-related diseases is now being developed by Rejuvenate Bio into a treatment for mitral valve disease and other deadly conditions in dogs, with the goal of helping man’s best friend live longer, healthier lives. Credit: Wyss Institute at Harvard University -
Video/AnimationAAV Capsid EngineeringWyss researchers have created a high-throughput platform to generate an Adeno-associated virus 2 (AAV2) library containing 200,000 variants, each carrying a distinct mutation in the virus capsid protein. Their analysis identified capsid changes that enhanced “homing” potential to specific organs in mice and virus viability, as well as a new protein hidden in the capsid-encoding... -
Audio/PodcastFrom the Old Chemistry Set to the New ‘BioBits,’ Cutting-Edge Kit to Teach BiologyFrom the Old Chemistry Set to the New ‘BioBits,’ Cutting-Edge Kit to Teach Biology was originally broadcast on WBUR on November 23, 2018. This story features Wyss Core Faculty member James Collins. The original broadcast story can be found here. -
Video/AnimationBioBitsResearchers at the Wyss Institute, MIT, and Northwestern University have collaborated to create “BioBits,” a low-cost, shelf-stable educational kit to teach synthetic and molecular biology in K-12 classrooms. The kit utilizes freeze-dried cell-free reactions that eliminate the need for growing living cells in order to perform biological experiments. Different modules in the kit teach students... -
Video/AnimationTEDx Beacon Street Salon: Reversing Human AgingWyss Institute Core Faculty member George Church, Ph.D., was the opening speaker at the TEDx Beacon Street saloon event hosted at the Franklin Park Zoo. He presented from inside the tapir cage! Talk summary: Animals can be an extremely useful resource in prolonging human lives and promoting general health. For example, there are organs in... -
Audio/PodcastFormer DI Hoopster Searches For Athletic Boost In The MicrobiomeFormer DI Hoopster Searches For Athletic Boost In The Microbiome was originally broadcast on WBUR’s Only a Game on August 4, 2017. The story features Wyss Core Faculty member George Church and Postdoctoral Fellow Jonathan Scheiman. The original broadcast story can be found here. -
Video/AnimationCRISPR-Cas: Molecular RecordingIn this video, Wyss Institute and Harvard Medical School researchers George Church and Seth Shipman explain how they engineered a new CRISPR system-based technology that enables the chronological recording of digital information, like that representing still and moving images, in living bacteria. Credit: Wyss Institute at Harvard University -
Audio/PodcastBiofilms: Reprogramming Bacteria to Improve LivesWyss Core Faculty member Neel Joshi and Postdoctoral Fellow Anna Duraj-Thatte discuss the intersection between synthetic biology and materials science as an underexplored area with great potential to positively affect our daily lives—applications ranging from manufacturing to medicine. Dr. Joshi outlines ways that his lab at the Wyss Institute is looking at reprogramming bacteria in... -
Audio/PodcastDisruptive: Sports GenomicsWith 100 trillion cells in the human body, bacteria outnumber our own human cells 2 to 1. These bacteria make up one’s microbiome, and particularly bacteria in our guts affect all our key organ functions. They play a role in our health, development and wellness, including endurance, recovery and mental aptitude. In this episode of... -
Video/AnimationWyss Study: Memory GenesResearchers at the Wyss Institute and the Personal Genome Project (PGP) are using Lumosity games to evaluate memory functions and response times. The genomes of high performers will be sequenced, with the goal of uncovering the relationship between genetics, memory, attention, and reaction speed. This video featuring George Church, Core Faculty of the Wyss Institute and Professor... -
Audio/PodcastDisruptive: Fluorescent In Situ SequencingDeveloped at the Wyss, FISSEQ (fluorescent in situ sequencing) is a spatial gene sequencing technology that reads and visualizes the three-dimensional coordinates of RNA and mRNAs – the working copies of genes – within whole cells and tissues. FISSEQ affords insights into biological complexity that until now have not been possible. In this episode of... -
Audio/PodcastFireside Chat with George ChurchAudio recording of a fireside chat with Wyss Core Faculty member George Church at the 2016 Convergence Forum, held in Chatham, Mass. on May 12 and 13, 2016. Moderated by Alison Taunton-Rigby. -
Audio/PodcastDisruptive: Molecular RoboticsHow can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for... -
Audio/PodcastGeorge Church: Responsibility, art & science of intentional extinction, de-extinction & agingGeorge Church Responsibility, art & science of intentional extinction, de-extinction & aging Wednesday, Feb 17, 2016 ArtScience @ Le Lab Lecture Series: Art, Design, Engineering & Biology – Core Faculty from the Wyss Institute for Biologically Inspired Engineering at Harvard University discuss how the arts and design are informing the frontiers of science. ArtScience @... -
Audio/PodcastMusings on Science and Society, with a dash of CRISPRThe Science Soapbox team sits down with Dr. George Church to talk everything from the dawn of CRISPR to the place of science fiction in society. Dr. Church is Professor of Genetics at Harvard Medical School, leader of the Synthetic Biology Platform at the Wyss institute, and director of PersonalGenomes.org. This episode was recorded on... -
Video/AnimationCRISPR-Cas9: Safeguarding Gene DrivesIn this animation, learn how effective safeguarding mechanisms developed at the Wyss Institute and Harvard Medical School can be applied to ensure gene drive research is done responsibly in the laboratory. These safeguards enable responsible scientific investigation into how gene drives could one day be leveraged for the greater good of human health, agriculture, and... -
Video/AnimationCRISPR-Cas9: Gene Target TroubleshootingIn this animation, learn how a “library on library” approach was used to create a software algorithm that can predict the best way to target any specific gene. Using the most effective RNA sequence, which can be selected using the novel software’s ranking and scoring algorithm, the gene editing mechanism known as CRISPR-Cas9 can be... -
Audio/PodcastDisruptive: Synthetic BiologyWhat sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat waste water, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to... -
Video/AnimationCas9: As a Transcriptional ActivatorIn this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationDesigning Fusion-Protein TherapiesIn this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss... -
Video/AnimationCRISPR-Cas9: Gene DrivesThis animation explains how an emerging technology called “gene drives” may be used to potentially spread particular genomic alterations through targeted wild populations over many generations. It uses mosquitoes as an example of a target species – and illustrates how the versatile genome editing tool called CRISPR makes it possible. Credit: Wyss Institute at Harvard... -
Video/AnimationFluorescent in situ SequencingIn this video, George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School, explains how fluorescent in situ sequencing could lead to new diagnostics that spot the earliest signs of disease, and how it could help reveal how neurons in the brain connect and function. Credit:... -
Video/AnimationInformation Storage in DNAGeorge Church and Sriram Kosuri discuss the benefits of using DNA as a storage medium and the approach they developed. Credit: Wyss Institute at Harvard University -
Video/AnimationMagnetic YeastIn this video, Wyss Core Faculty member Pamela Silver describes how her team at the Wyss Institute and Harvard Medical School induced magnetic sensitivity in a non-magnetic organism. This technology could potentially be used to magnetize a variety of different cell types in medical, industrial and research applications. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA Nanorobot: Cell-Targeted, Payload-DeliveringThis video describes a cell-targeted, payload-delivering DNA nanorobot developed at the Wyss Institute that can trigger targeted therapeutic responses. This novel technology could potentially seek out cancer cells and cause them to self-destruct. Credit: Wyss Institute at Harvard University -
Video/AnimationIntroduction to Programmable NanoroboticsWhat if we could build programmable nanorobots to attack disease? Credit: Wyss Institute at Harvard University -
Audio/PodcastBuilding a Sustainable FutureIn this episode of Harvard Medical LabCast, Harvard Medical School Professor of Systems Biology and Wyss Institute Core Faculty, Pam Silver discusses engineering organisms that produce fuel and even food. Find out how she’s working to build a sustainable future through synthetic biology.