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COPDx: Rapid diagnostic to triage acute exacerbations
A point-of-care test based on new biomarkers to rapidly identify COPD patients who are high risk of acute exacerbations (AEs), determine the cause, and guide treatment.
Blood Clot Dx
An ultra-sensitive triage test that identifies patients at risk for blood clots before they happen, enabling proactive treatment to reduce complications and deaths across a wide range of conditions.
AminoX: Making Better Protein Drugs, Quicker and Cheaper
AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.
Ichor: Reversing Aging
Ichor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health.
HydroPEF: Portable Off-the-Grid Water Purification
The Problem Globally, more than 2 billion people are forced to use a drinking water source that is contaminated with bacteria, parasites, and other pathogens, and an estimated 502,000 people die each year from diarrhea as a result of unsafe water. While a majority of the world has access to improved water sources, many are...
Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious Disease
Our novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains.
eRapid: Multiplexed Electrochemical Sensors for Fast, Accurate, Portable Diagnostics
Handheld electrochemical sensors have revolutionized at-home medical testing for diabetics, but they have not yet been successfully applied to diagnosing other conditions. These sensors are based on the activity of an enzyme, and there are only a limited number of enzymes that can be used to detect biomarkers of human disease. An alternative, much more...
Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering.
Plastivores: Plastic-Degrading Super-Microbes and Enzymes
The Plastic Degradation project identifies microbes from natural sources that have a low-level ability to degrade multiple types of plastic. In the laboratory, with the help of synthetic biology, those microbes then are evolved into much more effective plastic-eating microbes that, in the future, could be globally deployed to decompose plastic waste.
Sugar-to-Fiber Enzyme for Healthier Food
In collaboration with Kraft Heinz, our sugar-to-fiber product can convert sugar in food products into prebiotic fiber in the human gut, reducing the amount of sugar absorbed into the bloodstream without altering the amount of sugar in existing food product recipes.
FeCILL: Targeted Treatment for Severe Fungal Infections
FeCILL is novel delivery vehicle for antifungal drugs that targets them right to the infection site and reduces harmful side effects in patients with severe fungal infections.
CogniXense for Rare Disease Drug Discovery
Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
eRapid: Multiplexed Electrochemical Detection of Complex Diseases
StataDX licensed the eRapid portable electrochemical sensing technology to develop diagnostics for neurological, cardiovascular, and renal diseases with a first focus on building a point-of-care platform for difficult-to-detect neurological disorders.
Origami-Inspired Radiant Cooling for Improved Thermal Health
Origami-inspired Radiant Cooling devices for a broad range of building interiors use microfluidic water-circuits and foldable designs that increase their surface area to achieve more effective cooling.
OrbitSeq: A Collaborative Digital Hub for Life Sciences Data
OrbitSeq is a digital platform that empowers life sciences researchers to browse, upload, and analyze datasets, and easily collaborate with each other to bring science closer together and speed up the pace of discovery.
FcMBL: Broad-Spectrum Pathogen Capture for Infectious Disease Diagnosis and Therapy
The Problem Infectious diseases have plagued humanity for millennia, and the pathogens that infect and sicken humans are constantly evolving. Severe infections can cause sepsis, a life-threatening condition in which a patient’s immune system overreacts to the infection. The body starts to attack itself, which can lead to tissue damage, organ failure, and death. Sepsis...
CogniXense: A Platform for Rapid Drug Repurposing
CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month.
abbieSense: Anaphylaxis Diagnostic
The molecule histamine plays a primary role in the anaphylaxis reaction, which is a major cause of illness and death in people with severe allergies. Histamine is a very small molecule composed of only seventeen atoms, making it a challenging target to detect. To date, no diagnostic test exists that can measure histamine levels accurately...
RAPID: Testing for Food Contaminants
Contamination of food by microorganisms such as certain bacteria, viruses and fungi is a constant concern, with even miniscule amounts of certain species posing a risk for foods to become unsafe and spoiled during storage. Current safety and quality tests are often not sensitive enough to detect rare species, and because they first require the...
Microfluidic Drug Encapsulation
Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...
Project Abbie
Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications, and insect bites. Every three minutes, a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug epinephrine, as soon as an attack...
Bioplastics
Humans have produced roughly 8,300 million metric tons of plastic since the 1950s, the vast majority of which has been thrown out as waste. Only about 9% of that plastic waste has been recycled and 12% has been incinerated, leaving 79% of it to accumulate on our land and oceans, harming the environment, the food...
NanoRx: Mechanically-Activated Drug Targeting
The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
Omniphobic material that empowers a new category of medical devices
Cerulean Scientific is using our thin layer perfluorocarbon technology to develop medical devices that resist clotting, obstruction and infection, reducing patient suffering and lowering healthcare costs for the 10% of the population treated with an implantable medical device.
DNA Data Storage
The genetic material DNA has garnered considerable interest as a medium for digital information storage because its density and durability are superior to those of existing silicon-based storage media. For example, DNA is at least 1000-fold more dense than the most compact solid-state hard drive and at least 300-fold more durable than the most stable...
LactoRING for a Healthy Vaginal Microbiome
LactoRING is a novel slow-release vaginal ring designed to ensure continuous replenishment of Lactobacillus, promoting a healthy vaginal microbiome for a longer duration. The slow-release mechanism and targeted delivery to the vaginal environment will enhance the efficacy and convenience of treatment, thereby providing a comprehensive approach to vaginal dysbiosis management.
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.
Treating Breast Cancer that Metastasizes to the Brain
Treating breast cancer that has metastasized to the brain is an extreme challenge because most drugs are not able to cross the blood-brain barrier (BBB). About one in three patients with HER2+ or triple negative breast cancer will develop brain metastases, which leads to high morbidity and mortalities. There is currently no effective, systemic treatment...
StopEndoPain: Therapeutics for Endometriosis Associated Pain
Endometriosis is a common disease affecting 10% of women globally, making it one of the largest unaddressed indications in the world. It is associated with infertility and significant, frequently debilitating pain. Understanding its pain mechanisms is critical for targeted endometriosis treatments. We are developing in vitro models of ectopic endometrial lesions and studying connections to...
ENDOx: Early Diagnosis, Imaging, and Treatment of Endometriosis
Endometriosis, characterized by the abnormal growth of tissue resembling the endometrium outside the uterus, is estimated to affect 10–15% of women globally and is a leading cause of chronic pelvic pain. It often begins in adolescence, but limited understanding of its early development continues to delay diagnosis and the ability to treat it effectively. Current...
TORCH: Discovering Ovarian Torsion Biomarkers through Proteomics
Ovarian torsion (OT) is a serious medical condition where an ovary twists around the tissue that supports it, which can cut off blood supply to the ovary and sometimes the fallopian tube, causing severe pain. If blood flow is not quickly restored, the ovary might need to be surgically removed. Current diagnostic methods are often...
BioControl: Safe and Reversible Birth Control
The long-term impact of birth control remains largely unknown, and as our knowledge of traditional methods evolves, so must our innovations to uncover safe, effective, and non-hormonal options. By way of novel compounds that slow sperm function, this technology is offering a new form of male and vaginal contraceptive. Our early tests show promising results,...
OvaVasc: Enhanced Ovarian Tissue Engraftment for Fertility
Nearly 80% of women who survive cancer go on to struggle with fertility. Our team is developing an innovative approach using ovarian tissue cryopreservation: freezing and storing ovarian tissue to preserve fertility potential. By combining patient-derived cells and innovative techniques, we are accelerating tissue engraftment, boosting pregnancy rates, and preserving vital ovarian function. Our multidisciplinary...
Bacterial Vaginosis-Fertility Link
Infertility is a global health issue affecting 186 million people worldwide. It can be linked to microbiome interactions in the cervix, especially women with bacterial vaginosis (BV), a condition affecting 30% of women of reproductive age. Our microfluidic Cervix Chip model provides the first evidence that BV-related infections can impair sperm function due to an...
FernScore: Diagnosing bacterial vaginosis for reproductive health
Vaginal infections, especially bacterial vaginosis (BV), are a major concern for women’s health. Current diagnosis methods are subjective and often miss the mark, particularly for asymptomatic women. Researchers have developed a promising new approach using a test that analyzes the fern-like patterns formed when cervical mucus dries on a slide. Healthy mucus forms distinct fern...
Chronic Fatigue Syndrome
Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating illness that disproportionately affects women, causing severe fatigue, cognitive difficulties, sleeping problems, dizziness, and pain. Currently, no treatment exists for ME/CFS. Our team is creating accurate disease models to study brain activity, with the aim of understanding if ME/CFS is caused by continuous activation of interconnected brain...
Stroma Tx: Safe Pregnancy for IBD Patients
Patients with Inflammatory Bowel Disease (IBD) are advised to achieve remission before pregnancy, in an effort to decrease pregnancy-related intestinal issues, including fibrosis. Yet the exact mechanisms underlying the fluctuation of their symptoms remain unclear and there are no treatments currently available. To close this knowledge gap, we are treating our IBD Organ Chips with...
IBD ID: Finding Novel Anti-Inflammatory Drugs
Inflammatory Bowel Disease (IBD) disproportionately affects women, who also experience IBD symptoms differently than men. Through research with human Organ Chips, we identified the role of connective tissue in aggravating inflammation in the nearby intestinal cells of IBD patients. We will use this chip technology to enable rapid screening of stromal cells, crucial for understanding...
Autograph: Multiplex Autoantibody Detection and Monitoring for Women’s Autoimmune Health
Autoimmune diseases disproportionately affect women, with 80% of individuals suffering from these conditions being female. These diseases often lead to chronic and debilitating symptoms. Early and accurate diagnosis is crucial for effective management. Multi-analyte differentiation of protein biomarkers holds immense promise in distinguishing between various autoimmune diseases, enabling tailored treatment plans. To improve patient outcomes,...
Self-Monitoring for IVF Success: Developing Point-of-Care Sensors for Personalized Fertility Treatment
Fertility treatments like in-vitro fertilization (IVF) offer hope to many struggling with infertility, yet success rates remain below 40% for women under 40 in the U.S. The emotional, physical, and financial strains of failed IVF cycles highlight the urgent need for improved technologies that enhance the effectiveness and accessibility of these treatments. Current monitoring methods...
Solutions to Preterm Labor
Preterm birth affects over 13 million infants annually and is a leading cause of childhood mortality and lifelong disability. In the U.S., it disproportionately impacts Black infants (14.6%) compared to Hispanic (10.0%) and White (9.4%) infants, leading to severe health issues like cerebral palsy and sensory impairments, and causing trauma for parents. Effective diagnostics and...
Physiological Mucus-producing Organ-on-a-Chip Model of Human Cervix for Analysis of Host-microbiome Contributions to Vaginal Health
Interactions between a woman’s microbiome and the microenvironment of the reproductive tract are crucial for vaginal health. Disruptions of the microbial balance can lead to conditions like HIV, bacterial vaginosis, miscarriage and preterm birth. Yet current research methods, such as microbial cultures and metagenomic analysis, often fail to replicate the cervicovaginal environment accurately. Our Cervix...

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