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Blood Clot Dx
An ultra-sensitive triage test that identifies patients at risk for blood clots before they happen, enabling proactive treatment to reduce complications and deaths across a wide range of conditions.
ReConstruct: Vascularized Tissue for Breast Reconstruction and Augmentation
ReConstruct is a platform for growing, vascularizing, and implanting patient-derived tissues that enable safer breast reconstruction after cancer surgery.
HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies
The HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies.
Soft Robotic Glove for Neuromuscular Rehabilitation
The soft robotic glove helps restore lost hand function in patients with neurological conditions using inflatable chambers that gently bend and straighten the fingers repeatedly. Wyss startup Imago Rehab launched in 2021 to commercialize this technology for at-home rehabilitation of stroke survivors, and aims to expand its offerings into other areas of rehabilitation.
SomaCode: Getting Cell Therapies Where They Need to Go
SomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective.
Athlete-Derived Probiotics
FitBiomics is commercializing probiotic supplements based on unique combinations of microbes found in elite athletes’ guts to help optimize the health and function of all humans.
Biomaterial Scaffolds for T Cell Expansion
Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying...
Implantable Cancer Vaccine
The implantable cancer vaccine is an aspirin-sized disc that is implanted under the skin and serves as an artificial lymph node, recruiting and training a patient's own immune cells to find and kill their cancer cells. It was validated in a Phase I clinical trial at the Wyss Institute, and is currently being developed by Novartis to treat melanoma.
Focused Rotary Jet Spinning for Heart Implants
Focused rotary jet spinning (FRJS) is a manufacturing technique that can rapidly spin polymers into long fibers that are easily shaped into heart valves for treating a variety of cardiac diseases in children and adults.
T Cell Traps
T cells, a subtype of white blood cells, play key roles in cell-mediated immunity, be it to fight infections and cancer or, when corrupted, to react against the body’s own cells in more than 80 autoimmune diseases, including type I diabetes, multiple sclerosis, rheumatoid arthritis and others. However, isolating disease-related T cells from the body...
Project Abbie
Over 15 million Americans are at risk of anaphylaxis, a severe allergic reaction triggered by exposure to certain foods, materials, medications, and insect bites. Every three minutes, a food reaction sends someone to the emergency room. In most individuals, anaphylactic shock can be prevented by administering the counteracting drug epinephrine, as soon as an attack...
Vibrating Insoles for Better Balance
Balance in humans relies on complex feedback from the senses that govern the body’s mechanical stability. Wyss Institute and Boston University researchers have discovered that random vibrations, too gentle to be felt, can improve the sensory feedback system and may restore stability through a mechanism known as “stochastic resonance”. By incorporating vibrating elements in insoles...
Active Mattress for Infant Health
Wyss pediatric biotech startup Prapela is commercializing a gently vibrating mattress pad that helps soothe infants and normalize their breathing. This medical device can be used to address a variety of health conditions, including infant apnea and neonatal opioid withdrawal syndrome.
Flexi-Mitts: Neuromoter and Cognitive Ability Tracker
Advances in medical care have improved the survival of very low birth weight premature infants but at the same time have also led to an increased number of surviving infants with reduced cerebral growth and long-term neurodevelopmental motor, cognitive, and social morbidities. These complications are met by a lack of early assessment tools for diagnosing...
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.
EmuLAAte: Device-Based Stroke Prevention
Prefabricated, “one-size-fits-all” medical implants fail to match individual anatomies and can result in tissue damage and impaired healing. To address this concern, we’re pioneering transcatheter technology to create custom implants directly inside patients, tailored to their unique anatomy, to provide safer and more effective treatments across various medical conditions. As a first application, we are...
Self-Monitoring for IVF Success: Developing Point-of-Care Sensors for Personalized Fertility Treatment
Fertility treatments like in-vitro fertilization (IVF) offer hope to many struggling with infertility, yet success rates remain below 40% for women under 40 in the U.S. The emotional, physical, and financial strains of failed IVF cycles highlight the urgent need for improved technologies that enhance the effectiveness and accessibility of these treatments. Current monitoring methods...
Personalized Drug Dosing Diagnosis
Personalized dosing is the future of medication, moving towards treatments based on individual needs. Current dosing practices are based on average responses from limited clinical trials, overlooking variations due to gender, race, and genetics. Women are frequently excluded from this research and risk receiving dosages designed for men, which increases the chance of adverse effects....

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