Search Results for “brain”

Engineered Brain Organoids
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...
Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.
Soft hydrogel electrodes for better, safer implants
Soft, conductive hydrogels match the physical properties of the human brain, enabling the creation of electrodes and implantable devices that can improve brain-machine interfaces while reducing the risk of injury.
CogniXense for Rare Disease Drug Discovery
Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
CogniXense: A Platform for Rapid Drug Repurposing
CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month.
Soft Robotic Shoulder Support for Stroke Rehabilitation
The majority of stroke survivors have difficulty using their affected arm in everyday life. Commercial rehabilitation robots exist, but most are expensive, rigid, non-portable exoskeletons that can only be used in clinical rehabilitation settings. Portable devices could considerably increase the frequency and amount of robotic therapy, maximizing the recovery possible for patients with arm impairments....
Wearable Stochastic Resonance Technology for Supporting Neurological Function
Accelera has licensed the Wyss Institute’s stochastic resonance technology to develop fully wearable medical devices that support neurological function in patients with cerebral palsy and other conditions.
Treating Breast Cancer that Metastasizes to the Brain
Treating breast cancer that has metastasized to the brain is an extreme challenge because most drugs are not able to cross the blood-brain barrier (BBB). About one in three patients with HER2+ or triple negative breast cancer will develop brain metastases, which leads to high morbidity and mortalities. There is currently no effective, systemic treatment...
Extracellular Vesicles for Biomarker Detection
A non-invasive method to identify biomarkers of disease across cell types and develop diagnostics and monitoring systems.
GC Therapeutics: Changing the Future of Cell Therapies
GC Therapeutics (GCTx) is applying their stem cell-engineering TFome platform to overcome barriers in the development and manufacturing of cell therapies to improve patient access across a broad range of disease areas.
Tunable ECMs for More Effective T cell Therapies
Tunable hydrogels that enhance the efficacies of adoptively transferred immune cells during their manufacturing by mimicking target tissue biomechanics.
eRapid: Multiplexed Electrochemical Detection of Complex Diseases
StataDX licensed the eRapid portable electrochemical sensing technology to develop diagnostics for neurological, cardiovascular, and renal diseases with a first focus on building a point-of-care platform for difficult-to-detect neurological disorders.
Tough Gel Adhesives for Wound Healing
A Band-Aid® adhesive bandage is an effective treatment for stopping external bleeding from skin wounds, but an equally viable option for internal bleeding does not yet exist. Surgical glues are often used inside the body instead of traditional wound closure techniques like stitches, staples, and clips because they reduce the patient’s time in the hospital...
Synthetic Adeno-Associated Virus (AAV) Capsids for Advanced Gene Therapy
Dyno Therapeutics is aiming to become a leading gene therapy delivery partner for companies in this space, and to enable a new generation of more effective, safer gene therapies by harnessing optimized AAV capsids.
FISSEQ: Fluorescent In Situ Sequencing
Working copies of active genes — called messenger RNAs or mRNAs —translate the genetic information present in DNA into proteins within the cells’ multiple compartments. They are often positioned strategically within cells in ways that contribute critically to how cells and tissues grow, develop and function, and their mislocation can lead to disease development. To...
Active Mattress for Infant Health
Wyss pediatric biotech startup Prapela is commercializing a gently vibrating mattress pad that helps soothe infants and normalize their breathing. This medical device can be used to address a variety of health conditions, including infant apnea and neonatal opioid withdrawal syndrome.
NanoRx: Mechanically-Activated Drug Targeting
The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...
RoboBees: Autonomous Flying Microrobots
Inspired by the biology of a bee, researchers at the Wyss Institute are developing RoboBees, manmade systems that could perform myriad roles in agriculture or disaster relief. A RoboBee measures about half the size of a paper clip, weighs less that one-tenth of a gram, and flies using “artificial muscles” compromised of materials that contract when...
Omniphobic material that empowers a new category of medical devices
Cerulean Scientific is using our thin layer perfluorocarbon technology to develop medical devices that resist clotting, obstruction and infection, reducing patient suffering and lowering healthcare costs for the 10% of the population treated with an implantable medical device.
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health.

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