Technologies search results
19 Results for 'organ-on-a-chip'
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Ropirio: Novel Treatments Targeting the Lymphatic System
Ropirio is commercializing the world’s first drug that directly targets and reactivates lymph vessels, a portfolio of other lymph-targeting small molecules, and a preclinical platform for discovering more. -
Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering. -
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health. -
Sugar-to-Fiber Enzyme for Healthier Food
In collaboration with Kraft Heinz, our sugar-to-fiber product can convert sugar in food products into prebiotic fiber in the human gut, reducing the amount of sugar absorbed into the bloodstream without altering the amount of sugar in existing food product recipes. -
Blood Clot Dx
An ultra-sensitive triage test that identifies patients at risk for blood clots before they happen, enabling proactive treatment to reduce complications and deaths across a wide range of conditions. -
3D Bioprinting of Living Tissues
The Problem There is a severe shortage of human organs for people who need transplants due to injury or disease: more than 103,000 people are on the waiting list for organs in the US, and it’s estimated that 17 people die waiting for an organ transplant every day. Growing full organs from living human... -
Physiological Mucus-producing Organ-on-a-Chip Model of Human Cervix for Analysis of Host-microbiome Contributions to Vaginal Health
Interactions between a woman’s microbiome and the microenvironment of the reproductive tract are crucial for vaginal health. Disruptions of the microbial balance can lead to conditions like HIV, bacterial vaginosis, miscarriage and preterm birth. Yet current research methods, such as microbial cultures and metagenomic analysis, often fail to replicate the cervicovaginal environment accurately. Our Cervix... -
LactoRING for a Healthy Vaginal Microbiome
LactoRING is a novel slow-release vaginal ring designed to ensure continuous replenishment of Lactobacillus, promoting a healthy vaginal microbiome for a longer duration. The slow-release mechanism and targeted delivery to the vaginal environment will enhance the efficacy and convenience of treatment, thereby providing a comprehensive approach to vaginal dysbiosis management. -
Bacterial Vaginosis-Fertility Link
Infertility is a global health issue affecting 186 million people worldwide. It can be linked to microbiome interactions in the cervix, especially women with bacterial vaginosis (BV), a condition affecting 30% of women of reproductive age. Our microfluidic Cervix Chip model provides the first evidence that BV-related infections can impair sperm function due to an... -
IBD ID: Finding Novel Anti-Inflammatory Drugs
Inflammatory Bowel Disease (IBD) disproportionately affects women, who also experience IBD symptoms differently than men. Through research with human Organ Chips, we identified the role of connective tissue in aggravating inflammation in the nearby intestinal cells of IBD patients. We will use this chip technology to enable rapid screening of stromal cells, crucial for understanding... -
Lymphatics Medicines for Female Health
Lymphedema is a painful condition affecting millions of women worldwide, often caused by surgical treatment of breast and gynecologic cancers, or a biological predisposition. While no medicines are currently available to address lymphatic disease, we are combining a bioengineered human lymphatic-on-chip platform, lymphatic cell biology, and drug development expertise in an interdisciplinary effort to transform... -
Solutions to Preterm Labor
Preterm birth affects over 13 million infants annually and is a leading cause of childhood mortality and lifelong disability. In the U.S., it disproportionately impacts Black infants (14.6%) compared to Hispanic (10.0%) and White (9.4%) infants, leading to severe health issues like cerebral palsy and sensory impairments, and causing trauma for parents. Effective diagnostics and... -
Modeling for UTIs
Our team is developing pre-clinical female urethra and bladder chip models to better understand lower urinary tract organs in support of women’s health and UTI prevention. The cells and cell buffers from these organ chip models will be analyzed for protein differences created by the presence of infection. All results will be analyzed bioinformatically to... -
NodeTX: Growing Lymph Nodes to Treat Cancer
NodeTX is a novel immunotherapy that leverages the human body's innate ability to grow lymph nodes to fight tumors. -
Ichor: Reversing Aging
Ichor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health. -
Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious Disease
Our novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains. -
Kidney Engineering Technology for New Tissue Replacement Therapies
Trestle Biotherapeutics licensed 3D bioprinting, and stem cell and kidney organoid engineering methods to help it create kidney repair and replacement therapies. These could become new standard-of-care options beyond dialysis and kidney transplants for patients with kidney failure. -
FernScore: Diagnosing bacterial vaginosis for reproductive health
Vaginal infections, especially bacterial vaginosis (BV), are a major concern for women’s health. Current diagnosis methods are subjective and often miss the mark, particularly for asymptomatic women. Researchers have developed a promising new approach using a test that analyzes the fern-like patterns formed when cervical mucus dries on a slide. Healthy mucus forms distinct fern... -
Stroma Tx: Safe Pregnancy for IBD Patients
Patients with Inflammatory Bowel Disease (IBD) are advised to achieve remission before pregnancy, in an effort to decrease pregnancy-related intestinal issues, including fibrosis. Yet the exact mechanisms underlying the fluctuation of their symptoms remain unclear and there are no treatments currently available. To close this knowledge gap, we are treating our IBD Organ Chips with...