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Technologies 21

Engineered Brain Organoids
The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...
Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.
Soft hydrogel electrodes for better, safer implants
Soft, conductive hydrogels match the physical properties of the human brain, enabling the creation of electrodes and implantable devices that can improve brain-machine interfaces while reducing the risk of injury.
CogniXense for Rare Disease Drug Discovery
Unravel Biosciences has licensed a Wyss drug discovery platform technology to identify and create drugs to treat complex central nervous system disorders, starting with Rett syndrome.
CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.
CogniXense: A Platform for Rapid Drug Repurposing
CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month.

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Scientist II
Research and Technology Development

We are looking for a talented scientist to lead the development and characterization of our antibody brain shuttle compounds and to optimize our shuttles for specific payloads in neurodegenerative diseases. Reporting to the Principal Scientist, you will work closely with our team, Brain Targeting Program (BTP), using both in vitro cellular systems and in vivo humanized mouse models. You will determine brain PK/PD profiles of our shuttle compounds, their biophysical properties, and assess therapeutic applications. The mission of the Wyss BTP is to develop a robust modular brain delivery platform that is able to deliver large-molecule therapeutics for diverse brain diseases. We aim to help expand the pipeline of CNS drugs by making our platform broadly available to companies, academics and non-profit organizations. [004160SR]

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Visiting Student & Internship Opportunities
Academic Position
The Wyss Institute does not currently offer a formal internship program. If you are interested in working at the Wyss, please email your CV and research background to Laura Falloon, Academic Affairs Manager at laura.falloon@wyss.harvard.edu, for consideration for current or future opportunities. Please also indicate which Wyss teams best align with your background and research interests.

You can explore our Advanced Technology Team member profiles to learn more about what Wyss scientists are working on and which teams may be the best fit for your interests.

My time at the Wyss was an opportunity to work in a collaborative academic environment that helped me confirm I wanted to pursue a research career in the future!
Daniel Aluko, Former Visiting Undergraduate Research Fellow in the Ingber Lab

My research stay as a Visiting Graduate Researcher in the Brain Targeting Program at the Wyss Institute provided me with excellent preparation for my current PhD, both in terms of theoretical knowledge and advanced methodologies.
Marvin Porsiel, Former Visiting Graduate Student in the Brain Targeting Program
- 1/7 Wyss visiting students are invited to attend the annual Wyss Retreat. Credit: Wyss Institute at Harvard University
- 2/7 Visiting students and interns attend Wyss symposia and events with their team members, such as the Wyss Brain Targeting Program's annual meeting with external partners. Credit: Wyss Institute at Harvard University
- 3/7 Visiting students and interns participate in Institute-wide social gatherings such as our annual Halloween costume party. Credit: Wyss Institute at Harvard University
- 4/7 Visiting students and interns are members of large and small project teams. The CircaVent team is pictured here at the 2023 Wyss Retreat. Credit: Wyss Institute at Harvard University
- 5/7 Wyss Institute interns gain hands-on experience working with multidisciplinary teams in state-of-the-art lab facilities. Credit: Wyss Institute at Harvard University
- 6/7 Visiting students and interns attend Wyss Meet and Greets and other social events. Credit: Wyss Institute at Harvard University
- 7/7 Visiting students and interns attend Wyss Meet and Greets and other social events. Credit: Wyss Institute at Harvard University
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