In this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human Organ Chips, which offer the possibility of replacing animal testing and advancing personalized medicine. He also describes the burgeoning discipline of Biologically Inspired Engineering and the Institute he founded to develop bioinspired technologies to solve some of the world’s greatest challenges in medicine and the environment. The work he describes breaks down boundaries between science, engineering, art, and design, and demonstrates that there are no boundaries to creativity.