Technology Area: Nanodevices
98 Results for 'Nanodevices'
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Technologies 7
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Customizable scaffolds for faster, higher-quality T cell production
Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying... -
Toehold switches as versatile tools for synthetic biology applications
The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices... -
DNA Nanostructures for Drug Delivery
Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program... -
Putting Biofilms to Work
A team at the Wyss Institute sees biofilms as a robust new platform for designer nanomaterials that could treat inflammatory bowel diseases, clean up polluted rivers, manufacture pharmaceutical products, fabricate new textiles, and more. A novel protein engineering system called BIND, which stands for Biofilm-Integrated Nanofiber Display, could be the essential ingredient in tomorrow’s probiotic... -
Multiplexed Molecular Force Spectroscopy
Programmable DNA nanoswitches, invented at the Wyss Institute, can now be used in combination with a benchtop Centrifuge Force Microscope (CFM) as a highly reliable tool to observe thousands of individual molecules and their responses to mechanical forces in parallel. By analyzing the responses of single molecules under conditions where they experience such forces, it is possible... -
Inexpensive Super-Resolution Microscopy
Wyss Institute scientists have developed a highly versatile and inexpensive microscopic imaging platform designed to visualize objects with molecular-scale resolution and unprecedented complexity. The DNA-powered imaging technology can reveal the inner workings of cells at the single molecule level, using conventional microscopes found in most laboratories. Key to the Wyss Institute’s DNA-driven imaging super resolution...
News 73
Multimedia 18
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Video/AnimationPrimer Exchange ReactionIn this video, Jocelyn Kishi illustrates how Primer Exchange Reaction (PER) cascades work to autonomously create programmable long single-stranded DNA molecules. Credit: Wyss Institute at Harvard University. -
Video/AnimationAuto-cyclic Proximity RecordingThis video explains how “Auto-cycling Proximity Recording” works to identify pairs of nearby molecular targets and how it can be used as a tool to decipher the geometry of 3-dimensional engineered and natural molecules. Credit: Wyss Institute at Harvard University -
Audio/PodcastDisruptive: Mechanotherapeutics – From Drugs to WearablesMechanobiology reveals insights into how the body’s physical forces and mechanics impact development, physiological health, and prevention and treatment of disease. The emerging field of Mechanotherapeutics leverages these insights towards the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Audio/PodcastDisruptive: Molecular RoboticsHow can DNA be programmed to build novel structures, devices, and robots? We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for... -
Video/AnimationDetecting Zika: A platform for rapid, low-cost diagnosticsIn this video, a team of collaborators led by Wyss Core Faculty member James Collins discuss a low-cost, paper-based diagnostic system that they developed for detecting specific strains of the Zika virus, with the goal that it could soon be used in the field to easily screen blood, urine, or saliva samples. Credit: Wyss Institute...