Cross-disciplinary team from Harvard University and Dana-Farber Cancer Institute brings novel therapeutic cancer vaccine to human clinical trials
Date: Sep 6, 2013
This disk-shaped, biodegradable sponge contains growth factors and components of each patient's tumors. Researchers at the Wyss Institute and clinicians at Dana-Farber Cancer Institute hope that when it's implanted under the patient's skin, it will spur the patient's immune system to attack the patient's tumors and destroy them.
A cross-disciplinary team of scientists, engineers, and clinicians announced today that they have begun a Phase I clinical trial of an implantable vaccine to treat melanoma, the most lethal form of skin cancer.
The effort is the fruit of a new model of translational research being pursued at the Wyss Institute for Biologically Inspired Engineering at Harvard University that integrates the latest cancer research with bioinspired technology development. It was led by Wyss Core Faculty member David J. Mooney, Ph.D., who is also the Robert P. Pinkas Family Professor of Bioengineering at the Harvard School of Engineering and Applied Sciences (SEAS), and Wyss Institute Associate Faculty member Glenn Dranoff, M.D., who is co-leader of Dana-Farber Cancer Institute's Cancer Vaccine Center.
Most therapeutic cancer vaccines available today require doctors to first remove the patient's immune cells from the body, then reprogram them and reintroduce them back into the body. The new approach, which was first reported to eliminate tumors in mice in Science Translational Medicine in 2009, the year the Wyss Institute was launched, instead uses a small disk-like sponge about the size of a fingernail that is made from FDA-approved polymers. The sponge is implanted under the skin, and is designed to recruit and reprogram a patient's own immune cells "on site," instructing them to travel through the body, home in on cancer cells, then kill them.
The technology was initially designed to target cancerous melanoma in skin, but might have application to other cancers. In the preclinical study reported in Science Translational Medicine, 50 percent of mice treated with two doses of the vaccine -- mice that would have otherwise died from melanoma within about 25 days -- showed complete tumor regression.
"Our vaccine was made possible by combining a wide range of biomedical expertise that thrives in Boston and Cambridge," said Mooney, who specializes in the design of biomaterials for tissue engineering and drug delivery. "It reflects the bioinspired engineering savvy and technology development focus of engineers and scientists at the Wyss Institute and Harvard SEAS, as well as the immunological and clinical expertise of the researchers and clinicians at Dana-Farber and Harvard Medical School."
Wyss Institute scientists Core Faculty member David Mooney, Ph.D. (left) and Senior Staff Scientist Ed Doherty (right) explain how their implantable, biodegradable cancer vaccine could help overcome melanoma, and how the Institute's unique model of technology translation is speeding the vaccine to the clinic.
Watch video. . .
"This is expected to be the first of many new innovative therapies made possible by the Wyss Institute's collaborative model of translational research that will enter human clinical trials," said Wyss Founding Director Don Ingber, M.D., Ph.D., who is also the Judah Folkman Professor of Vascular Biology at Harvard Medical School and Boston Children's Hospital, and a Professor of Bioengineering at Harvard SEAS. "It validates our approach, which strives to move technologies into the clinical space much faster than would be possible in a traditional academic environment. It's enormously gratifying to see one of our first technologies take this giant leap forward."
The Wyss Institute comprises a consortium of researchers, engineers, clinicians, and staff with industrial and business development experience from the Wyss Institute and nine other collaborating institutions in Greater Boston.
"It is rare to get a new technology tested in the laboratory and moved into human clinical trials so quickly," said Dranoff, who is also a Professor of Medicine at Harvard Medical School, and Leader of the Dana-Farber/Harvard Cancer Center Program in Cancer Immunology. "We're beyond thrilled with the momentum, and excited about its potential."
Recruitment of participants for the clinical trial began recently under the leadership of F. Stephen Hodi, Jr., M.D., Director of Dana-Farber's Melanoma Center and Associate Professor of Medicine at Harvard Medical School. The goal of the Phase I study, which is expected to conclude in 2015, is to assess the safety of the vaccine in humans.
The cancer vaccine work has received support from the Wyss Institute, Dana-Farber, and the National Institutes of Health. In addition to Mooney, Dranoff, and Hodi, other collaborators include Wyss Senior Staff Scientist Edward Doherty, Wyss Staff Scientist Omar Ali, M.D., Jerry Ritz, M.D., Director of the Cell Processing Laboratory at Dana-Farber, Sara Russell, M.D. and Charles Yoon, M.D., surgeons at Dana-Farber, and other clinical research team members based at Dana-Farber.
IMAGE and VIDEO available.
Wyss Institute for Biologically Inspired Engineering at Harvard University
Dan Ferber, email@example.com, +1 617-432-1547
Dana-Farber Cancer Institute
Bill Schaller, firstname.lastname@example.org, +1 617-632-5357
Harvard School of Engineering and Applied Sciences
Caroline Perry, email@example.com, +1 617-496-1351
Harvard Medical School
David Cameron, firstname.lastname@example.org,+1 617-432-0441
About the Wyss Institute for Biologically Inspired Engineering at Harvard University
The Wyss Institute for Biologically Inspired Engineering at Harvard University (http://wyss.harvard.edu) uses Nature's design principles to develop bioinspired materials and devices that will transform medicine and create a more sustainable world. Working as an alliance among Harvard's Schools of Medicine, Engineering, and Arts & Sciences, and in partnership with Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Boston Children's Hospital, Dana Farber Cancer Institute, Massachusetts General Hospital, the University of Massachusetts Medical School, Spaulding Rehabilitation Hospital, Boston University and Tufts University, the Institute crosses disciplinary and institutional barriers to engage in high-risk research that leads to transformative technological breakthroughs. By emulating Nature's principles, Wyss researchers are developing innovative new engineering solutions for healthcare, energy, architecture, robotics, and manufacturing. These technologies are translated into commercial products and therapies through collaborations with clinical investigators, corporate alliances, and new start-ups. The Wyss Institute recently won the prestigious Webby Award, as well as the World Technology Network award for innovation in biotechnology.
About Dana-Farber Cancer Institute
Dana-Farber Cancer Institute is a principal teaching affiliate of the Harvard Medical School and is among the leading cancer research and care centers in the United States. It is a founding member of the Dana-Farber/Harvard Cancer Center, designated a comprehensive cancer center by the National Cancer Institute. It provides adult cancer care with Brigham and Women's Hospital as Dana-Farber/Brigham and Women's Cancer Center and it provides pediatric care with Boston Children's Hospital as Dana-Farber/Boston Children's Cancer and Blood Disorders Center. Dana-Farber is the top ranked cancer center in New England, according to U.S. News & World Report, and one of the largest recipients among independent hospitals of National Cancer Institute and National Institutes of Health grant funding. Follow Dana-Farber on Facebook and on Twitter.
About the Harvard School of Engineering and Applied Sciences
The Harvard School of Engineering and Applied Sciences (SEAS) serves as the connector and integrator of Harvard's teaching and research efforts in engineering, applied sciences, and technology. Through collaboration with researchers from all parts of Harvard, other universities, and corporate and foundational partners, we bring discovery and innovation directly to bear on improving human life and society. For more information, visit: http://seas.harvard.edu.
About Harvard Medical School
Harvard Medical School (hms.harvard.edu) has more than 7,500 full-time faculty working in 11 academic departments located at the School's Boston campus or in one of 47 hospital-based clinical departments at 16 Harvard-affiliated teaching hospitals and research institutes. Those affiliates include Beth Israel Deaconess Medical Center, Brigham and Women's Hospital, Cambridge Health Alliance, Boston Children's Hospital, Dana-Farber Cancer Institute, Harvard Pilgrim Health Care, Hebrew SeniorLife, Joslin Diabetes Center, Judge Baker Children's Center, Massachusetts Eye and Ear Infirmary, Massachusetts General Hospital, McLean Hospital, Mount Auburn Hospital, Schepens Eye Research Institute, Spaulding Rehabilitation Hospital and VA Boston Healthcare System.