Search results
352 Results for 'organ-on-a-chip'
Technologies 19
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Ropirio: Novel Treatments Targeting the Lymphatic System
Ropirio is commercializing the world’s first drug that directly targets and reactivates lymph vessels, a portfolio of other lymph-targeting small molecules, and a preclinical platform for discovering more. -
Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering. -
Human Organs-on-Chips
Organ Chips are microfluidic devices lined with living human cells for drug development, disease modeling, and personalized medicine. Launched in 2014, Wyss startup Emulate, Inc., is leveraging the Wyss Institute’s Organ Chip technology to mimic human organs in vitro, enabling faster, better, and cheaper drug development and insights into human health. -
Sugar-to-Fiber Enzyme for Healthier Food
In collaboration with Kraft Heinz, our sugar-to-fiber product can convert sugar in food products into prebiotic fiber in the human gut, reducing the amount of sugar absorbed into the bloodstream without altering the amount of sugar in existing food product recipes. -
Blood Clot Dx
An ultra-sensitive triage test that identifies patients at risk for blood clots before they happen, enabling proactive treatment to reduce complications and deaths across a wide range of conditions. -
3D Bioprinting of Living Tissues
The Problem There is a severe shortage of human organs for people who need transplants due to injury or disease: more than 103,000 people are on the waiting list for organs in the US, and it’s estimated that 17 people die waiting for an organ transplant every day. Growing full organs from living human...
Collaborations 3
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Kraft Heinz Partnership
The Kraft Heinz company approached the Wyss Institute for help to achieve its ambitious goal to make its food products healthier, resulting in a novel technology that is ripe for commercialization. -
Wyss AI DataHub
The Wyss Institute’s AI DataHub integrates patient samples, cutting-edge tissue models, and multi-omics technologies to generate rich, translational datasets – accelerating breakthroughs in drug discovery, biomarker development, and beyond through strategic partnerships. -
Wyss DxA Industrial Participant Program
As the industry-facing component of the Wyss Diagnostics Accelerator, the Industrial Participant Program is a collaboration hub between healthcare testing companies and the scientific and clinical community within the Wyss ecosystem that seeks to compress the timeframe for bringing new, high-impact, diagnostic technologies to market.
People 12
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Founding Director and Core Faculty
Donald E. Ingber, M.D., Ph.D. -
Research Assistant II - Organs-on-Chip and Intestinal Biology
Anushka Chadha -
Research Assistant III – Immune Organs-on-Chips
Sruthy Pallikonda Chakravarthy -
Postdoctoral Research Fellow
Shiyan Tang -
Postdoctoral Fellow
Ernest Tochukwu Aguinam -
Postdoctoral Fellow
Sara Rudolph
News 209
Multimedia 46
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Video/AnimationMice Don’t Menstruate: Reimagining Women’s Health Using Organ Chips with Dr. Donald IngberIn this episode, host Sharon Kedar, Co-Founder of Northpond Ventures, is joined by Dr. Donald Ingber, Founding Director at Wyss Institute for Biologically Inspired Engineering at Harvard University. Dr. Ingber’s commitment to following his passion has led him to countless medical and technological breakthroughs, including Organ Chip technology. These incredible chips recreate the structure and... -
Video/AnimationAtlantic Health Research Spotlight: Female-Reproductive-Tract Organ Chips for Women’s Health and Fertility StudiesInnovation has disrupted care as we know it. Challenges with access, complex diseases, and care delivery persist, but so do areas of opportunity for emerging tech and discoveries. The Atlantic explored gene editing, artificial intelligence, climate change, weight-loss and diabetes treatments, and more at their annual Health Summit. Wyss researchers Aakanksha Gulati, Ph.D., and Ola... -
Video/AnimationHow do we make safer and more effective drugs?Wyss researchers are using an ever-growing number of human tissue-mimicking Organ Chips to improve and accelerate the drug development process for a wide number of unmet diseases – and understand what causes them to erupt. More recently, they added a human Vagina Chip and personalized Barrett’s esophagus Chip to their arsenal, and created in vitro... -
Video/AnimationBridging science, engineering, and art: from mechanobiology to Human Organs-on-ChipsIn this Marsilius Lecture, Wyss Founding Director Don Ingber shares his personal path from a serendipitous experience in an undergraduate art class that led to his discovery of how living cells are constructed using “tensegrity” architecture and how this contributed to the birth of the field of Mechanobiology to his more recent work on human... -
Video/AnimationAVATARs for Astronaut Health Are Heading to Space!NASA’s AVATAR experiment is flying aboard Artemis II to study how deep space affects human health. Using Organ Chips containing astronaut cells, Emulate and Wyss Institute researchers will examine how radiation and microgravity impact human tissue. This research will help inform medical strategies for future long-duration missions to Mars and beyond. The findings could also... -
Audio/PodcastOrgans on Chips: Using Science, Art, and Design to Understand the Human Body – Talking About BloodIn this episode, Wyss Founding Director Don Ingber, M.D., Ph.D., talks with Helen Osborne about: How organ-on-chip and “human body on chips” technologies are built and how they realistically mimic human organ function by combining living cells, blood flow, and mechanical forces like breathing and stretch; The implications of these chips for hematology and clinical...
Publications 51
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January 20, 2026
Cell Stem Cell
Challenges and opportunities for human Organ Chips in FDA assessments and pharma pipelines
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February 27, 2023
Biochemical Journal
From tensegrity to human organs-on-chips: implications for mechanobiology and mechanotherapeutics
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December 27, 2023
Pharmacology, Research, & Perspectives
Human organ chips for regenerative pharmacology
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July 19, 2022
Physiology
What Can an Organ-on-a-Chip Teach Us About Human Lung Pathophysiology?
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June 6, 2022
Physiology
What can an organ-on-a-chip teach us about human lung physiology?
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March 25, 2022
Nature Reviews Genetics
Human organs-on-chips for disease modelling, drug development and personalized medicine
Jobs 1
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Postdoctoral Fellow – PKPD Modelling, Lung-on-Chip
Academic PositionThe lab of Don Ingber, M.D., Ph.D., Founding Director at the Wyss Institute for Biologically Inspired Engineering at Harvard University seeks outstanding postdoctoral applicants with expertise in lung biology, cancer biology, and/or infectious disease to join an interdisciplinary team of biologists and engineers using human Lung Organ Chips to study lung cancer progression, tumor-immune interactions, and respiratory infections in a clinically relevant context. [16122]
Events 11
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Mar 3, 2021, 11:00am - 3:00pmLecture
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Biologic drugs comprise 40 percent of the current drug development pipeline. Existing in vitro and animal models are limited in their ability to evaluate the safety and efficacy of these drugs in humans. These limitations often result in development delays and increased costs. Organs-on-chips emulate human biology by providing a micro-engineered environment lined with living... Free and open to public -
Jul 2, 2019, 12:00pmLecture
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Organs on chips are bioengineered systems designed to capture the complexities of human physiology in a microscale device. Perhaps most successfully applied in drug development to predict efficacy and toxicity earlier in the pipeline, organs on chips are also versatile platforms for studying tissue development and disease pathogenesis. Join Cell Press for a discussion with Donald... Free and open to public -
May 22, 2017, 1:00pm - 2:00pmLecture
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Wyss Institute Founding Director Donald E. Ingber, M.D., Ph.D., will discuss the potential for human organs on chips to revolutionize drug trials at Brigham and Women’s Hospital’s Pathology Grand Rounds seminar series on Monday, May 22. Accreditation Information Partners HealthCare System is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education... Free and open to public