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Technologies / Therapeutics

Therapeutics

We are using a multifaceted strategy to advance the development of better therapeutics and the discovery of new ones, using diverse approaches including predictive bioanalytics, machine learning, synthetic biology, and new preclinical models like human Organ Chips.

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Lactation Biologics: Increasing Milk Production for Healthier Babies
Lactation Biologics: Increasing Milk Production for Healthier Babies

Lactation Biologics is developing a long-lasting, self-injectable treatment to help nursing mothers feed their babies naturally, helping them get the best nutrition possible in the face of climate disasters and supply chain disruptions.

DNA Nanostructures for Drug Delivery
DNA Nanostructures for Drug Delivery

Researchers at the Wyss Institute have developed two methods for building arbitrarily shaped nanostructures using DNA, with a focus on translating the technology towards nanofabrication and drug delivery applications. One proprietary nanofabrication technique, called “DNA-brick self-assembly,” uses short, synthetic strands of DNA that work like interlocking Lego® bricks. It capitalizes on the ability to program...

Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications
Passive Directional Valve Technology: Towards More User-friendly and Accessible Microfluidic Devices for Diagnostic and Research Applications

Passive directional valves enable smaller and more complex microfluidics applications across of broad spectrum of future technologies, including diagnostics, drug development, and tissue engineering.

Tunable ECMs for more effective T cell therapies
Tunable ECMs for more effective T cell therapies

Tunable hydrogels that enhance the efficacies of adoptively transferred immune cells during their manufacturing by mimicking target tissue biomechanics.

Ichor: Reversing Aging
Ichor: Reversing Aging

Ichor is addressing multiple age-related diseases by identifying genetic interventions that reprogram old cells to a younger state. Therapies based on these interventions could improve survival for cancer patients and long-term cardiovascular and neurological health.

HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies
HarborSite: Precise and Efficient Gene Editing for Next-Generation Gene Therapies

The HarborSite next-generation gene therapy platform enables integration of therapeutic genes into genomic safe harbors using highly specific and efficient recombinases to enable more predictable, safe and durable gene therapies.

Metabolically Labeled CAR-T Cells Against Cancer
Metabolically Labeled CAR-T Cells Against Cancer

Through a simple and effective metabolic labeling approach, patient-derived T cells engineered to carry immune-enhancing cytokines on their surfaces could help expand adoptive T cell therapies to treatment of solid tumors and improve blood cancer therapies.

Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious Disease
Immunostimulatory RNA Therapeutic for Treatment of Cancer and Infectious Disease

Our novel dsRNAs stimulate the immune system to inhibit cancer, bacterial, and viral infections including SARS-CoV-2 and multiple influenza strains.

AminoX: Making Biologics Safer with Synthetic Biology and Advanced Chemistry
AminoX: Making Biologics Safer with Synthetic Biology and Advanced Chemistry

AminoX enables protein drugs to only become active in the tumor microenvironment and not elsewhere in the body to avoid immune-related adverse effects in the body. By designing and building non-standard amino acids into strategic positions of protein drugs, AminoX provides tumor-specific, and longer-lasting target inhibition.

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Single-Cell Encapsulation for Improved Cell Therapies

The Problem Mesenchymal stromal cells (MSCs) are valued for their ability to secrete compounds that modulate the body’s immune system, making them an attractive solution for existing problems with cell therapies including host-vs-graft disease and organ transplant rejections. However, MSCs are rapidly cleared from the body and can come under fire from the immune system....

DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines
DoriVac: Boosting Antigen-specific Immune Responses with DNA Origami-Based Vaccines

Personalized cancer and infectious disease vaccine platform harnessing DNA nanotechnology to control the co-delivery and co-presentation of tumor antigen and adjuvant ligands to immune cells with nanoscale precision. This approach has potential to trigger enhanced immune responses against tumors and infectious pathogens.

SomaCode: Getting Cell Therapies Where They Need to Go
SomaCode: Getting Cell Therapies Where They Need to Go

SomaCode is solving the problem of cell therapy delivery by identifying unique molecular “zip codes” for disease and engineering cells to home to those zip codes, making cell therapies safer and more effective.

DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery
DNA Nanoswitches: “Lab-on-a-Molecule” Drug Discovery

The Lab-on-a-Molecule platform leverages the Wyss Institute’s DNA nanotechnology technology for the high-throughput, low-cost screening of a wide range of chemical and biologic compounds to enable the discovery of first-in-class therapeutics for various conditions.

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Soft hydrogel electrodes for better, safer implants

Soft, conductive hydrogels match the physical properties of the human brain, enabling the creation of electrodes and implantable devices that can improve brain-machine interfaces while reducing the risk of injury.

FeCILL: Targeted Treatment for Severe Fungal Infections
FeCILL: Targeted Treatment for Severe Fungal Infections

FeCILL is novel delivery vehicle for antifungal drugs that targets them right to the infection site and reduces harmful side effects in patients with severe fungal infections.

Sparkle: Instant Biosensors for Real-Time Imaging
Sparkle: Instant Biosensors for Real-Time Imaging

Sparkle is revolutionizing the binder assay industry by harnessing novel chemistry to create instant fluorescent biosensors for a wide variety of uses.

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Pancreatitis Tx: An Engineered Protein Treatment for Pancreatitis

First disease-modifying therapy that can be systemically applied to safely and effectively treat patients with different forms of pancreatitis.

Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from Antibiotics
Engineered Live Biotherapeutic Product (eLBP) to Protect the Microbiome from Antibiotics

eLBP is a safe and cost-effective therapeutic for patients treated with beta-lactam antibiotics that safeguards against the loss of health-essential microbes while preventing the development and spread of antibiotic resistance.

CircaVent: A Drug Discovery Platform for Mental Health Conditions
CircaVent: A Drug Discovery Platform for Mental Health Conditions

CircaVent is a novel drug discovery platform that combines predictive algorithms, high-throughput preclinical models, and human organoids to identify and test drugs that could treat mental health conditions like bipolar disorder.

MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation
MRBL: Next-Generation Gene Therapy for Molecular Skin Rejuvenation

The next-generation gene therapy for molecular skin rejuvenation combines a comprehensive target gene prediction with a novel transdermal delivery approach for therapeutic adenovirus-associated viruses. The platform targets monogenic disease indications in the skin, and extends the same targets to the treatment of common skin aging conditions.

Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More
Cellular “Backpacks” to Fight Cancer, Autoimmune Disorders, and More

Macrophages are very malleable immune cells, but that also means that they can be influenced by cancerous tumors and inflammatory processes. Our cellular "backpacks" stick to macrophages and can deliver molecules that keep them in their desired state for cell therapy and more.

DNA Nanotechnology Tools: From Design to Applications
DNA Nanotechnology Tools: From Design to Applications

A suite of diverse, multifunctional DNA nanotechnological tools with unique capabilities and potential for a broad range of clinical and biomedical research areas. Our DNA nanotechnology devices were engineered to overcome specific bottlenecks in the development of new therapies and diagnostics, and to help further our understanding of molecular structures.

OMNIVAX: Broadly Deployable Infection Vaccine Platform
OMNIVAX: Broadly Deployable Infection Vaccine Platform

OMNIVAX is an immuno-material-based vaccine platform technology able to create safe and effective therapeutic and prophylactic vaccines against viral and bacterial threats. Its modular approach enables the rapid creation of vaccines for pathogens using known and unknown antigens. Current approaches include vaccines against some viral diseases.

Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution
Bone Marrow-Like Scaffolds for Accelerating Immune Reconstitution

An implantable bone marrow cryogel to accelerate the full reconstitution of the immune system, including T cell immunity, in patients that received chemotherapy and a bone marrow transplant. This could provide an off-the-shelf, material-based solution for patients with severe blood disorders whose immunity is recovering only slowly after treatment.

Injectable Alginate Hydrogels for Medical Applications
Injectable Alginate Hydrogels for Medical Applications

One of the biggest challenges in medicine is getting a drug to the right part of the body at the right time. Even when the target site in the body is known, like a pain-causing injury or a cancerous tumor, most drugs are given as oral pills or intravenous infusions, which limits their effectiveness. In...

CogniXense: A Platform for Rapid Drug Repurposing
CogniXense: A Platform for Rapid Drug Repurposing

CogniXense is a target-agnostic drug discovery platform that enables the repurposing of drugs for rare genetic diseases in record time. By combining human data-based computational drug prediction with on-demand animal model development, we can mimic the diversity of symptoms of patient populations and begin drug screening on new diseases within a month.

Biomaterial Scaffolds for T Cell Expansion
Biomaterial Scaffolds for T Cell Expansion

Immunotherapy, or tweaking the body’s own immune system to treat disease, is attracting significant attention in the medical field for its potential to offer long-lasting cures with fewer side effects than chemotherapy or other drugs. One type of immunotherapy involves isolating T cells (a type of white blood cell) from a patient’s body, sometimes modifying...

Toehold Switches for Synthetic Biology
Toehold Switches for Synthetic Biology

The burgeoning field of synthetic biology is designing artificial gene circuits that recognize molecules in their environment and respond by regulating genes with desired activities. In the future, such capabilities could allow the engineering of cells as diagnostic or therapeutic devices, factories for the production of clinically or industrially coveted molecules, and as specialized devices...

Engineered Brain Organoids
Engineered Brain Organoids

The ability to derive and manipulate pluripotent stem cells has opened up new avenues for modeling biological systems in both healthy and diseased conditions. In order to more fully recapitulate the tissue microenvironment with its cell-cell, cell-extracellular matrix, and cell-niche interactions, it is essential to transition stem-cell culturing from monolayers to 3D structures. Self-organization of...

Microfluidic Drug Encapsulation
Microfluidic Drug Encapsulation

Because of their large molecular sizes and properties, biologic drugs, be it in the form of monoclonal antibodies that target disease-associated molecules or active proteins and enzymes that may correct deficiencies in the human body, have proven difficult to deploy in many cases. Their therapeutic effects on target cells and tissues often require high and...

Focused Rotary Jet Spinning for Heart Implants
Focused Rotary Jet Spinning for Heart Implants

Focused rotary jet spinning (FRJS) is a manufacturing technique that can rapidly spin polymers into long fibers that are easily shaped into heart valves for treating a variety of cardiac diseases in children and adults.

Fusion Proteins for Reduced Drug Toxicity
Fusion Proteins for Reduced Drug Toxicity

Therapeutic variants of the natural hormone erythropoietin (EPO) which is produced in the kidney to boost the production of red blood cells are commonly used to treat anemias stemming from kidney disease, chemotherapy and other complications. However, many drugs that are based on therapeutic proteins, including EPO, often cause unwanted side effects because they not...

Cell-Free Biomolecule Manufacturing
Cell-Free Biomolecule Manufacturing

Wyss Institute researchers have developed a biomolecular manufacturing method that can quickly and easily produce a wide range of vaccines, antimicrobial peptides and antibody conjugates while doing so anywhere, even in places without access to electrical power or refrigeration. The breakthrough could provide a life-saving workaround for making modern interventions available in remote areas. Today...

NanoRx: Mechanically-Activated Drug Targeting
NanoRx: Mechanically-Activated Drug Targeting

The Wyss team has developed a novel drug targeting nanotechnology that is activated locally by mechanical forces, either endogenous high shear stresses in blood created by vascular occlusion or mechanical energy applied locally using low-energy ultrasound radiation. Today, vascular blockage is the leading cause of death and disability in United States and Europe. Current therapies...

3D Bioprinting of Living Tissues
3D Bioprinting of Living Tissues

Progress in drug testing and regenerative medicine could greatly benefit from laboratory-engineered human tissues built of a variety of cell types with precise 3D architecture. But production of greater than millimeter sized human tissues has been limited by a lack of methods for building tissues with embedded life-sustaining vascular networks. In this video, the Wyss...

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