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Video/AnimationeRAPID: a Platform for Portable DiagnosticseRapid is an electrochemical sensing platform that uses a novel antifouling coating to enable low-cost, multiplexed detection of a wide range of biomolecules for diagnostics and other applications. Credit: Wyss Institute at Harvard -
Video/AnimationWhat Is BIOMOD?BIOMOD is a biomolecular design competition for students created by the Wyss Institute for Biologically Inspired Engineering at Harvard University. Each year BIOMOD holds a Jamboree, an annual conference at which all BIOMOD teams convene to present their work from the summer. This year’s Jamboree will take place in Genentech Hall at UCSF in San Francisco,... -
Video/AnimationThe BeginningThe struggle for supremacy has begun. But only one will be victor. Only one will dictate the future for generations to come… Watch the new official trailer now. -
Video/AnimationAuto-cyclic Proximity RecordingThis video explains how “Auto-cycling Proximity Recording” works to identify pairs of nearby molecular targets and how it can be used as a tool to decipher the geometry of 3-dimensional engineered and natural molecules. Credit: Wyss Institute at Harvard University -
Video/AnimationFouling Marine FoulingMarine fouling occurs when organisms attach themselves to underwater objects like boats, rope, pipes and building structures. Mussels are one of the biggest culprits. Once attached, they are difficult to remove, leading to operational downtime, increased energy use and damage. Paints and coatings are currently used to prevent marine fouling, but are frequently toxin-based and not... -
Video/AnimationPodocyte Cells: Kidney-on-a-ChipThis video shows a 3-dimensional rendering of the glomerulus-on-a-chip with human stem cell-derived mature podocytes (in green) grown and differentiated in one channel (shown on top) and that extend their processes through the modeled glomerulus basement membrane towards glomerular vascular cells (in magenta) in the parallel running channel (shown on the bottom). Credit: Wyss Institute... -
Video/AnimationArtScience Talks @ Le Lab – Seeing Is Believing: Therapeutic Cancer VaccinesWyss Core Faculty member David Mooney presents a talk with Mary Mooney, titled Seeing Is Believing: Therapeutic Cancer Vaccines. Marshaling a patientÍs immune system to recognize and destroy cancerous cells is an exciting strategy to attack cancer, and this talk will explore materials that engage the immune system through science and artistic representation. Mary K.... -
Video/AnimationHow plant stems grow into different shapesIt is well known that as plants grow, their stems and shoots respond to outside signals like light and gravity. But if plants all have similar stimuli, why are there so many different plant shapes? Using simple mathematical ideas, Harvard University researchers constructed a framework that explains and quantifies the different shapes of plant stems.... -
Video/AnimationWyss Study: Memory GenesResearchers at the Wyss Institute and the Personal Genome Project (PGP) are using Lumosity games to evaluate memory functions and response times. The genomes of high performers will be sequenced, with the goal of uncovering the relationship between genetics, memory, attention, and reaction speed. This video featuring George Church, Core Faculty of the Wyss Institute and Professor... -
Video/Animation3D Printing Ceramic FoamThis video shows the 3D printing process that adds layer upon layer of the foam link to create a 3D porous ceramic honeycomb pattern. This new capability is an important step toward generating porous materials for lightweight structures, thermal insulation, tissue scaffolds and other applications. Credit: Lori Sanders -
Video/AnimationSoft Robotic Heart Sleeve: In VitroReplicating heart pressure and contraction in vitro, the soft robotic heart sleeve with actuators arranged around a fluid-filled sac is able to rhythmically contract to each time pump a defined fluid volume into the attached tubing. Credit: Harvard SEAS -
Video/AnimationReconfigurable MaterialsThis video shows how a reconfigurable model structure generated with the teams predictive method can be drawn into different shapes that might perform very different functions. Credit: Harvard School of Engineering and Applied Sciences. -
Video/Animation2016 8th Wyss Retreat Open AnimationThe 8th Annual Wyss Institute Retreat. Credit: Wyss Institute at Harvard University -
Video/AnimationShear-Thinning Biomaterial: Catheter InjectionThis movie shows the solid state of the shear-thinning biomaterial immediately after release from the catheter into an aqueous solution (00:04). The STB is cohesive and remains as one solid piece throughout the injection process. There is no noticeable dissolution of the STB into the solution, suggesting it is stable immediately after being discharged from... -
Video/Animation3D Printed Heart-on-a-ChipIn this video, learn how Wyss Institute and Harvard SEAS researchers have created a 3D-printed heart-on-a-chip that could lead to new customizable devices for short-term and long-term in vitro testing. Credit: Johan U. Lind (Disease Biophysics Group), Alex D. Valentine and Lori K. Sanders (Lewis Lab)/Harvard University -
Video/AnimationSmoking Human Lung Small Airway-on-a-ChipIn this video, Wyss Founding Director Donald Ingber and Technology Development Fellow Kambez Benam explain how the integrated smoking device mimics normal cigarette smoke exposure and how it can impact research into the causes of COPD and into new biomarkers and therapeutics. Credit: Wyss Institute at Harvard University -
Video/AnimationBioprinting: The Kidney’s Proximal TubulesIn this video, see how the Wyss Institute team has advanced bioprinting to the point of being able to fabricate a functional subunit of a kidney. Credit: Wyss Institute at Harvard University -
Video/AnimationRoot: Meets Students At Any LevelThis video demonstrates how Root can be used in classrooms to help instill coding and programming skills in students at any level. Developed by a team of researchers led by Wyss Core Faculty member Radhika Nagpal, the Root system is designed to be as intuitive and approachable as any tablet app, providing a framework easy... -
Video/AnimationMechanotherapeutics: From Drugs to WearablesThe Wyss Institute’s 7th annual international symposium focused on advances in the field of Mechanobiology that have resulted in the development of new types of pharmaceuticals, drug delivery systems, engineered tissues, and wearable therapeutic devices that leverage physical forces or target mechanical signaling pathways as a core part of their mechanism of action. Organized by... -
Video/AnimationOctobot: A Soft, Autonomous RobotThe Octobot is the first entirely soft, autonomous robot. It is made by a combination of embedded 3D printing, modeling, and soft lithography. Inspired by real octopuses, the Octobot has no rigid components. It is powered by a chemical reaction and controlled with a microfluidic logic that directs the flow of fuel. The logic circuit... -
Video/AnimationSuper Resolution Discrete Molecular Imaging AnimationSee in this animation, how Discrete Molecular Imaging (DMI) uses DNA nanotechnology to reveal densely packed molecular features in structures similar in size as single protein molecules. Credit: Wyss Institute at Harvard University -
Video/AnimationDiscrete Molecular ImagingWyss Institute Core Faculty member Peng Yin and his co-worker Mingjie Dai explain in this video, how Discrete Molecular Imaging (DMI) can be used to enhance their DNA-PAINT super-resolution imaging platform to visualize features on a single-molecule scale. Credit: Wyss Institute at Harvard University -
Video/AnimationLiquid Gated MembranesThe first part of this animation compares the transmembrane pressure (TMP) between a standard filter and a liquid gated membrane filter (depicted by pressure gauge in bottom right corner). The second part of the animation shows the tendency of each system to clog up due to fouling. The liquid gated membrane filter results in a... -
Video/AnimationRobobee: Saving Energy While in the AirThe RoboBee, pioneered at the Harvard Microrobotics Lab, uses an electrode patch and a foam mount that absorbs shock to perch on surfaces and conserve energy in flight. Credit: Harvard John A. Paulson School of Engineering and Applied Sciences (SEAS) -
Video/AnimationEfficient Recovery of Stem Cell SheetsSee in this video how an intact sheet of mesenchymal stem cells, stained with a violet dye, can be lifted off the infused polymer substrate in the culture dish using a filter paper and transferred to a new surface. Credit: Wyss Institute at Harvard University -
Video/AnimationDetecting Zika: A platform for rapid, low-cost diagnosticsIn this video, a team of collaborators led by Wyss Core Faculty member James Collins discuss a low-cost, paper-based diagnostic system that they developed for detecting specific strains of the Zika virus, with the goal that it could soon be used in the field to easily screen blood, urine, or saliva samples. Credit: Wyss Institute... -
Video/Animation3D Printing Metal in MidairIn this video, see the laser-assisted method developed by Wyss Core Faculty member Jennifer Lewis that allows metal to be 3D printed in midair. Credit: Lewis Lab / Wyss Institute at Harvard University -
Video/AnimationPrinting Vascular TissuePrinting vessel vasculature is essential for sustaining functional living tissues. Until now, bioengineers have had difficulty building thick tissues, lacking a method to embed vascular networks. A 3D bioprinting method invented at the Wyss Institute and Harvard SEAS embeds a grid of vasculature into thick tissue laden with human stem cells and connective matrix. Printed... -
Video/AnimationMeet Root: The Robot that Brings Code to LifeComputational thinking and programming underlie the digital world around us – yet K-16 teachers have been challenged to find the right teaching tool to instill coding and programming skills in beginners of a wide age range. Recognizing the pressing need for young students to be digitally literate and the remarkable educational power of robots, a... -
Video/AnimationSoft Robotic Grippers For Deep-Sea ExplorationIn this video, two types of soft robotic grippers are shown successfully collecting coral samples at the bottom of the Red Sea. The first gripper features opposing pairs of bending actuators, while the second gripper – inspired by the coiling action of a boa constrictor – can access tight spaces and clutch small and irregular... -
Video/Animation4D Printing: Shapeshifting ArchitecturesA team at the Wyss Institute and Harvard SEAS has developed a new microscale printing method to create transformable objects. These “4D-printed” objects go a step beyond 3D printing to incorporate a fourth dimension: time. The method was inspired by the way plants change shape over time in response to environmental stimuli. This orchid-shaped structure... -
Video/AnimationWyss Institute: A Technology RevolutionThere is a technology revolution – a revolution inspired by nature, built upon collaboration, self-assembly and disruptive innovation. The Wyss Institute is crossing boundaries and disrupting the status quo to pioneer new technologies, new devices, and new therapeutics that harness the power of life itself. There is a technology revolution and it is happening at... -
Video/AnimationSmall Airway-on-a-Chip: Modeling COPD and AsthmaDevelopment of new therapeutics for chronic lung diseases have been hindered by the inability to study them in vitro. To address this challenge, Wyss Institute researchers used their Organ-on-a-Chip technology to produce a microfluidic ‘human lung small airway-on-a-chip.’ The device, which is composed a clear rubber material, is lined by living Human lung small airway... -
Video/AnimationDistributed Cell Division CounterGenetically engineered E. coli containing a fluorescing red protein enabled a Wyss Institute and Harvard Medical School team to analyze the population fluctuations of gut microbes by comparing proportion of “marked” to “unmarked” cells. Credit: Wyss Institute at Harvard University -
Video/AnimationCRISPR-Cas9: Safeguarding Gene DrivesIn this animation, learn how effective safeguarding mechanisms developed at the Wyss Institute and Harvard Medical School can be applied to ensure gene drive research is done responsibly in the laboratory. These safeguards enable responsible scientific investigation into how gene drives could one day be leveraged for the greater good of human health, agriculture, and... -
Video/AnimationRoboBee: From Aerial to AquaticThe RoboBee is a miniature robot that has long been able to fly. But what if the RoboBee lands in water? Using a modified flapping technique, researchers at the Harvard John A. Paulson School of Engineering and Applied Sciences and the Wyss Institute for Biologically Inspired Engineering at Harvard University have demonstrated that the RoboBee... -
Video/AnimationPathogen-Extracting Sepsis TherapyThis video explains how sepsis induced by an overload of blood pathogens can be treated with the Wyss Institute’s improved pathogen-extracting, spleen-mimicking device. Blood is flown through a cartridge filled with hollow fibers that are coated with a genetically engineered blood protein inspired by a naturally-occurring human molecule called Mannose Binding Lectin (MBL). MBL is... -
Video/AnimationJumping on Water: Robotic Water StriderIn this video, watch how novel robotic insects developed by a team of Seoul National University and Harvard scientists can jump directly off water’s surface. The robots emulate the natural locomotion of water strider insects, which skim on and jump off the surface of water. Credit: Wyss Institute at Harvard University -
Video/Animation3D Printed Soft Jumping RobotUsing a multi-material 3D printer for manufacturing allowed Wyss Institute researchers to fabricate the jumping robot in one uninterrupted job, seamlessly transitioning from rigid core components to a soft exterior in a single print session. It’s first ever robot to be 3D printed with layers of material gradients, making it extremely durable and giving the... -
Video/AnimationBioinspired Robotics: Softer, Smarter, SaferThe Bioinspired Robotics platform at HarvardÍs Wyss Institute for Biologically Inspired Engineering looks into Nature to obtain insights for the development of new robotic components that are smarter, softer, and safer than conventional industrial robots. By looking at natural intelligence, collective behavior, biomechanics, and material properties not found in manmade systems, scientists at the Wyss... -
Video/AnimationCRISPR-Cas9: Gene Target TroubleshootingIn this animation, learn how a “library on library” approach was used to create a software algorithm that can predict the best way to target any specific gene. Using the most effective RNA sequence, which can be selected using the novel software’s ranking and scoring algorithm, the gene editing mechanism known as CRISPR-Cas9 can be... -
Video/AnimationPopup Challenge: Help Revolutionize Popup RoboticsJoin the Wyss Institute Popup Challenge, a design contest based around the laminate design techniques outlined at popupcad.org. We hope to grow the community of people who can design, build, and operate laminate devices and micromechanisms. If you are a student considering using popups for a class project, a researcher who has an application for... -
Video/AnimationMeet Metamorpho: A Robot Simulating Biological TransformationMetamorpho is a robotic platform designed for emulating the developmental induction of locomotor patterns across all animals. This video shows a robotic system with a transforming body morphology that simulates the biological transformation of a tadpole to a frog. Like a tadpole, Metamorpho starts to swim with tail alone while legs receive a feedback signal... -
Video/AnimationGastrointestinal Re-ProgrammingIn this animation, see an example of how genetically engineered microbes being developed by researchers at the Wyss Institute could detect and treat a wide range of gastrointestinal illnesses and conditions. Credit: Wyss Institute at Harvard University -
Video/AnimationAntibiotic EfficacyIn this video, Wyss Institute Core Faculty member James Collins and Michael Lobritz explain how antibiotics can have vastly different effects on pathogenic bacteria and suggest potential implications for improving antibiotic treatments in infected patients. Credit: Wyss Institute at Harvard University -
Video/AnimationCircadian TransplantThe first successful transplant of a circadian rhythm into a naturally non-circadian species could lead to precisely timed release of drugs and other innovative therapeutic applications. In this video, gut bacteria (E. coli) exhibit a circadian rhythm after circadian oscillators were transferred from cyanobacteria. The ‘mother cell’ at the top blinks on and off with... -
Video/AnimationSoft Robotic GloveThe soft robotic glove under development at the Wyss Institute could one day be an assistive device used for grasping objects, which could help patients suffering from muscular dystrophy, amyotrophic lateral sclerosis (ALS), incomplete spinal cord injury, or other hand impairments to regain some daily independence and control of their environment. This research is partially... -
Video/AnimationEnvironmental Impact: Chitin-Inhibiting Pesticides Called into QuestionChitin, a molecule that serves a purpose in the developmental biology of insects, fungi and shrimp, has long been a target of growth-inhibiting pesticides due to the belief that it did not exist in vertebrates. For decades, chitin-inhibiting pesticides have stunted the growth of insects and fungi to protect valuable crops. Now, research from the... -
Video/AnimationCas9: As a Transcriptional ActivatorIn this technical animation, Wyss Institute researchers instruct how they engineered a Cas9 protein to create a powerful and robust tool for activating gene expression. The novel method enables Cas9 to switch a gene from off to on and has the potential to precisely induce on-command expression of any of the countless genes in the... -
Video/AnimationMotion Capture LabThe Wyss InstituteÍs Motion Capture Lab is a state of the art facility designed to measure and analyze human motion. It allows Wyss Institute scientists and their collaborators to design, build and test assistive technologies, ultimately accelerating the translation of new devices to improve human lives. Credit: Wyss Institute at Harvard University -
Video/AnimationFluid GateIn this video, the fluid-based gating mechanism separates gas and water. The fluid-filled pores system leverages pressurization to control the opening and closing of its liquid gates, making it extremely precise at separating mixed materials. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA NanoswitchesGel electrophoresis, a common laboratory process, sorts DNA or other small proteins by size and shape using electrical currents to move molecules through small pores in gel. The process can be combined with novel DNA nanoswitches, developed by Wyss Associate Faculty member Wesley Wong, to allow for the simple and inexpensive investigation of life’s most... -
Video/AnimationHuman Organs-On-ChipsWyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each individual organ-on-chip is composed of a clear flexible polymer... -
Video/AnimationWyss Institute: Stay InspiredThe Wyss Institute has fueled a rapid uptick in translational technologies propelled into real-world applications, as was evident by the presentation of the year’s highlights during the Institute’s Sixth Annual Retreat. The Retreat was held November 17, 2014 at Boston’s Seaport World Trade Center and was attended by roughly 600 members of the Institute community.... -
Video/AnimationGene Editing Mechanism of CRISPR-Cas9In this animation, learn how CRISPR-Cas9 gene editing technology can be used to precisely disrupt and modify specific genes. Credit: Wyss Institute at Harvard University. -
Video/AnimationDesigning Fusion-Protein TherapiesIn this video, watch the new computational model in action as it simulates the behavior of a fusion-protein drug molecule after the targeting protein has attached to a cell. Developed by Wyss researchers, this model helps design more effective biologic drugs while eliminating drug candidates that are prone to causing side effects. Credit: Harvard’s Wyss... -
Video/AnimationToehold SwitchesIn this animation, Wyss Institute Postdoctoral Fellow Alex Green, Ph.D., the lead author of “Toehold Switches: De-Novo-Designed Regulators of Gene Expression”, narrates a step-by-step guide to the mechanism of the synthetic toehold switch gene regulator. Credit: Wyss Institute at Harvard University -
Video/AnimationProgrammable Paper: Advances in Synthetic BiologyWyss Institute scientists discuss the collaborative environment and team effort that led to two breakthroughs in synthetic biology that can either stand alone as distinct advances – or combine forces to create truly tantalizing potentials in diagnostics and gene therapies. Credit: Wyss Institute at Harvard University. -
Video/AnimationBioinspired Blood Repellent CoatingIn this video, Wyss Institute Founding Director Don Ingber, Core Faculty member Joanna Aizenberg, Staff Scientist Dan Leslie and Postdoctoral Fellow Anna Waterhouse explain how a coating they developed using FDA-approved materials could prevent blood clotting in medical devices without the use of blood thinners. Credit: Wyss Institute at Harvard University -
Video/AnimationBIND BiofilmIn this video Wyss Institute Core Faculty member Neel Joshi and Postdoctoral Fellow Peter Nguyen describe how their protein engineering system called BIND (Biofilm-Integrated Nanofiber Display) could be used to redefine biofilms as large-scale production platforms for biomaterials that can be programmed to provide functions not possible with existing materials. An animation depicts how it... -
Video/AnimationGyrification: How the Brain Got its FoldsA team led by Wyss Institute Core Faculty member L. Mahadevan used numerical simulations and a physical gel model to answer an age-old question that has vexed scientists for years: how did the outer layer of the mammalian brain (gray matter) become so convoluted atop the brain’s inner white matter? It turns out that at... -
Video/AnimationKilobots: A Thousand-Robot SwarmIn this video, Kilobots self-assemble in a thousand-robot swarm. The algorithm developed by Wyss Institute Core Faculty member Radhika Nagpal that enables the swarm provides a valuable platform for testing future collective Artificial Intelligence (AI) algorithms. Credit: Harvard School of Engineering and Applied Sciences. -
Video/AnimationDynamic Daylight Redirection SystemThis video shows Keojin Jin conducting a shoebox test that shows the light reflection effect to the top surface of the box as well as the reduction of direct light to the bottom surface of the box. Credit: Wyss Institute at Harvard University -
Video/AnimationSelf-Folding RobotsIn this video, Wyss Institute Core Faculty member Rob Wood, who is also the Charles River Professor of Engineering and Applied Sciences at Harvard’s School of Engineering and Applied Sciences (SEAS), and SEAS Ph.D. student Sam Felton discuss their landmark achievement in robotics – getting a robot to assemble itself and walk away autonomously –... -
Video/AnimationCRISPR-Cas9: Gene DrivesThis animation explains how an emerging technology called “gene drives” may be used to potentially spread particular genomic alterations through targeted wild populations over many generations. It uses mosquitoes as an example of a target species – and illustrates how the versatile genome editing tool called CRISPR makes it possible. Credit: Wyss Institute at Harvard... -
Video/AnimationSoft Robotic ExosuitIn this video, Harvard faculty member Conor Walsh and members of his team explain how the biologically inspired Soft Exosuit targets enhancing the mobility of healthy individuals and restoring the mobility of those with physical disabilities. This research is partially funded by the National Science Foundation. Note: This technology is currently in the research and... -
Video/Animation3D Printing: Cellular CompositesMaterials scientists at Harvard University have created lightweight cellular composites via 3D printing. These fiber-reinforced epoxy composites mimic the structure and performance of balsa wood. Because the fiber fillers align along the printing direction, their local orientation can be exquisitely controlled. These 3D composites may be useful for wind turbine, automotive and aerospace applications, where... -
Video/AnimationBioinspired Approach to Sepsis TherapyWyss Institute Founding Director Don Ingber, Senior Staff Scientist Michael Super and Technology Development Fellow Joo Kang explain how they engineered the Mannose-binding lectin (MBL) protein to bind to a wide range of sepsis-causing pathogens and then safely remove the pathogens from the bloodstream using a novel microfluidic spleen-like device. Credit: Wyss Institute at Harvard... -
Video/AnimationImplantable Cancer VaccineThis animation explains how the Wyss Institute cancer vaccine technology developed in collaboration with biologists, clinicians and researchers at the Institute, the Dana-Farber Cancer Institute and Harvard’s School of Engineering and Applied Sciences works by reprogramming the immune system to reject cancer cells. Credit: Wyss Institute at Harvard University -
Video/AnimationBone Marrow-on-a-ChipWyss Institute Founding Director Don Ingber, Postdoctoral Fellow Yu-suke Torisawa, and Researcher Catherine Spina explain how and why a they built bone marrow-on-a-chip, and how they got it to act like whole living marrow and manufacture blood cells. Credit: Wyss Institute at Harvard University -
Video/AnimationVirus-inspired DNA NanodevicesWyss Institute Core Faculty member William Shih and Technology Development Fellow Steven Perrault explain why DNA nanodevices need protection inside the body, and how a viral-inspired strategy helps protect them. Credit: Wyss Institute at Harvard University -
Video/AnimationTough GelA team at the Wyss Institute is honing a tough, rubbery hydrogel initially developed at Harvards School of Engineering and Applied Sciences. The gel is 90 percent water, yet it stretches without breaking to more than 20 times its original length and recoils like rubber, the researchers first reported in Nature in 2012. In fact,... -
Video/AnimationDNA CagesTo create supersharp images of their cage-shaped DNA polyhedra, the scientists used DNA-PAINT, a microscopy method that uses short strands of DNA (yellow) labeled with a fluorescent chemical (green) to bind and release partner strands on polyhedra corners, causing them to blink. The blinking corners reveal the shape of structures far too small to be... -
Video/AnimationShrinking GelWhen the temperature rises to just below body temperature, this biocompatible gel shrinks dramatically within minutes, bringing tooth-precursor cells (green) closer together. Credit: Basma Hashmi -
Video/AnimationSustainability: The Ultimate ChallengeIn the past century plastic has transformed modern-day life on our planet, but is it sustainable? We produce 300 million tons of plastic per year* and recycle only 3%**. Are we content that the other 97% collects in oceans, landfills and the food chain? The challenge is clear: we will drown in plastic if we... -
Video/AnimationChitosan BioplasticIn this video, the team grew a California Blackeye pea plant in soil enriched with its chitosan bioplastic over a three-week period – demonstrating the material’s potential to encourage plant growth once it is returned to the environment. Credit: Wyss Institute at Harvard University -
Video/AnimationFluorescent in situ SequencingIn this video, George Church, Ph.D., a Core Faculty member at the Wyss Institute and Professor of Genetics at Harvard Medical School, explains how fluorescent in situ sequencing could lead to new diagnostics that spot the earliest signs of disease, and how it could help reveal how neurons in the brain connect and function. Credit:... -
Video/AnimationTERMESInspired by termites, the TERMES robots act independently but collectively. They can carry bricks, build staircases, and then climb them to add bricks to a structure. Credit: Wyss Institute at Harvard University -
Video/AnimationBioprinting: Building in Blood VesselsBuilding in blood vessels. Then they addressed a big challenge in tissue engineering: embedding 3D vascular networks. They developed a ‘fugitive’ ink that can easily be printed, then suctioned off to create open microchannels that can then be populated with blood-vessel-lining cells to allow blood to flow. Read more: wyss.harvard.edu/viewpressrelease/141 Credit: Wyss Institute at Harvard... -
Video/AnimationBioprinting: Building with Bio-InksBuilding with bio-inks. Using their custom-built printer, the fugitive ink for the vasculature, and other biological inks containing extracellular matrix and human cells, the researchers printed a 3D tissue construct. Credit: Wyss Institute at Harvard University -
Video/AnimationBioprinting: Building Intricate StructuresBuilding intricate structures. The team first designed a custom printer that can precisely co-print multiple materials in 3D to create intricate heterogeneous patterns. Credit: Wyss Institute at Harvard University -
Video/AnimationNew coating turns glass into superglassA transparent new coating makes ordinary glass tough, ultraslippery, and self-cleaning. The coating is based on SLIPS — the world’s slipperiest synthetic substance. Here, a droplet of dyed octane quickly beads up and rolls off a watch glass with the new coating. To learn more, go to Credit: Wyss Institute at Harvard University -
Video/AnimationTiny 3D-Printed BatteryIn this video, a 3D-printer nozzle narrower than a human hair lays down a specially formulated “ink” layer by layer to build a microbattery’s anode from the ground up. Unlike ink in an office inkjet printer, which comes out as droplets of liquid and wets a piece of paper, these 3D-printer inks are specially formulated... -
Video/AnimationBuilding 3D Structures with DNA BricksThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying ‘recipe’ of DNA base pairs. This animation accurately shows how the DNA strands self assemble to build a structure.DNA Nanostructures... -
Video/AnimationNanoRx: Clot-Busting NanotherapeuticIn this animation, learn how the Wyss Institute clot-busting nanotherapeutic is activated by fluid high shear force – which occurs where blood flows through vessels narrowed by obstruction – to specifically target clots and dissolve them away. By pairing this drug with an intra-arterial device that restores blood flow to complete obstructions, the drug-device combination... -
Video/AnimationMeTro HydrogelsAn international team led by the Wyss Institute recently used microfabrication techniques to design a new micropatterned hydrogel that shows great promise for tissue engineering — cardiac tissue in particular. It incorporates an elastic protein called tropoelastin, which is found in all elastic human tissues. The Wyss Institute’s Ali Khademhosseini discusses the research. Credit: Wyss... -
Video/AnimationWyss Institute: The Adventure ContinuesWyss Institute Retreat 2012. Credit: Wyss Institute at Harvard University -
Video/AnimationDNA Bricks: Molecular AnimationThe nanofabrication technique, called ‘DNA-brick self-assembly,’ uses short, synthetic strands of DNA that work like interlocking Lego bricks. It capitalizes on the ability to program DNA to form into predesigned shapes thanks to the underlying “recipe” of DNA base pairs. Animation created by Digizyme for the Wyss Institute. Credit: Wyss Institute at Harvard University -
Video/AnimationResearchers mimic pulmonary edema in Lung-on-a-ChipThe Wyss Institute’s human breathing lung-on-a-chip, made using human lung and blood vessel cells, acts much like a lung in a human body. A vacuum re-creates the way the lungs physically expand and contract during breathing. As reported in Science Translational Medicine on November 7, 2012, Wyss researchers have now mimicked a human disease –... -
Video/AnimationSLIPS‘SLIPS’ technology, inspired by the slippery pitcher plant that repels almost every type of liquid and solid, is a unique approach to coating industrial and medical surfaces that is based on nano/microstructured porous material infused with a lubricating fluid. By locking in water and other fluids, SLIPS technology creates slick, exceptionally repellent and robust self-cleaning... -
Video/AnimationVibrating Mattress: Preventing Infant ApneaWhat if we could prevent infant apnea? Credit: Wyss Institute at Harvard University -
Video/AnimationMaking Structures with DNA “Building Blocks”Researchers at the Wyss Institute have developed a method for building complex nanostructures out of short synthetic strands of DNA. Called single-stranded tiles (SSTs), these interlocking DNA “building blocks,” akin to Legos, can be programmed to assemble themselves into precisely designed shapes, such as letters and emoticons. Credit: Wyss Institute at Harvard University -
Video/AnimationTermite-inspired robotsInspired by termites and their building activities, the TERMES project is working toward developing a swarm construction system in which robots cooperate to build 3D structures much larger than themselves. The current system consists of simple but autonomous mobile robots and specialized passive blocks; the robot is able to manipulate blocks to build tall structures,... -
Video/AnimationIntroduction to Organs-on-a-ChipWhat if we could test drugs without animal models? Wyss Institute researchers and a multidisciplinary team of collaborators have engineered microchips that recapitulate the microarchitecture and functions of living human organs, including the lung, intestine, kidney, skin, bone marrow and blood-brain barrier. These microchips, called ‘organs-on-chips’, offer a potential alternative to traditional animal testing. Each... -
Video/AnimationIntroduction to Sepsis DiagnosticWhat if we could diagnose sepsis in just hours, not days? Wyss Institute researchers discuss their approach to a rapid sepsis diagnostic. Credit: Wyss Institute at Harvard University -
Video/AnimationWyss Institute: Our ModelWhat if we could transform the future? This video explores the Wyss Institute model of translation. Credit: Wyss Institute at Harvard University -
Video/AnimationLung-on-a-ChipCombining microfabrication techniques with modern tissue engineering, lung-on-a-chip offers a new in vitro approach to drug screening by mimicking the complicated mechanical and biochemical behaviors of a human lung. This extended version of the video includes our findings when we mimicked pulmonary edema on the chip. Credit: Wyss Institute at Harvard University